Monday, July 31, 2017

MIT Quantum Computing Research

Ultracold Molecules Hold Promise
for Quantum Computing
New approach yields long-lasting configurations that could provide long-sought “qubit” material.
David L. Chandler | MIT News Office

July 27, 2017 -- Researchers have taken an important step toward the long-sought goal of a quantum computer, which in theory should be capable of vastly faster computations than conventional computers, for certain kinds of problems. The new work shows that collections of ultracold molecules can retain the information stored in them, for hundreds of times longer than researchers have previously achieved in these materials.

These two-atom molecules are made of sodium and potassium and were cooled to temperatures just a few ten-millionths of a degree above absolute zero (measured in hundreds of nanokelvins, or nK). The results are described in a report this week in Science, by Martin Zwierlein, an MIT professor of physics and a principal investigator in MIT's Research Laboratory of Electronics; Jee Woo Park, a former MIT graduate student; Sebastian Will, a former research scientist at MIT and now an assistant professor at Columbia University, and two others, all at the MIT-Harvard Center for Ultracold Atoms.

Many different approaches are being studied as possible ways of creating qubits, the basic building blocks of long-theorized but not yet fully realized quantum computers. Researchers have tried using superconducting materials, ions held in ion traps, or individual neutral atoms, as well as molecules of varying complexity. The new approach uses a cluster of very simple molecules made of just two atoms.

“Molecules have more ‘handles’ than atoms,” Zwierlein says, meaning more ways to interact with each other and with outside influences. “They can vibrate, they can rotate, and in fact they can strongly interact with each other, which atoms have a hard time doing. Typically, atoms have to really meet each other, be on top of each other almost, before they see that there's another atom there to interact with, whereas molecules can see each other” over relatively long ranges. “In order to make these qubits talk to each other and perform calculations, using molecules is a much better idea than using atoms,” he says.

Using this kind of two-atom molecules for quantum information processing “had been suggested some time ago,” says Park, “and this work demonstrates the first experimental step toward realizing this new platform, which is that quantum information can be stored in dipolar molecules for extended times.”

“The most amazing thing is that [these] molecules are a system which may allow realizing both storage and processing of quantum information, using the very same physical system,” Will says. “That is actually a pretty rare feature that is not typical at all among the qubit systems that are mostly considered today.”

In the team’s initial proof-of-principle lab tests, a few thousand of the simple molecules were contained in a microscopic puff of gas, trapped at the intersection of two laser beams and cooled to ultracold temperatures of about 300 nanokelvins. “The more atoms you have in a molecule the harder it gets to cool them,” Zwierlein says, so they chose this simple two-atom structure.  

The molecules have three key characteristics: rotation, vibration, and the spin direction of the nuclei of the two individual atoms. For these experiments, the researchers got the molecules under perfect control in terms of all three characteristics — that is, into the lowest state of vibration, rotation, and nuclear spin alignment.

“We have been able to trap molecules for a long time, and also demonstrate that they can carry quantum information and hold onto it for a long time,” Zwierlein says. And that, he says, is “one of the key breakthroughs or milestones one has to have before hoping to build a quantum computer, which is a much more complicated endeavor.”

The use of sodium-potassium molecules provides a number of advantages, Zwierlein says. For one thing, “the molecule is chemically stable, so if one of these molecules meets another one they don't break apart.”

In the context of quantum computing, the “long time” Zwierlein refers to is one second — which is “in fact on the order of a thousand times longer than a comparable experiment that has been done” using rotation to encode the qubit, he says. “Without additional measures, that experiment gave a millisecond, but this was great already.” With this team’s method, the system’s inherent stability means “you get a full second for free.”

That suggests, though it remains to be proven, that such a system would be able to carry out thousands of quantum computations, known as gates, in sequence within that second of coherence. The final results could then be “read” optically through a microscope, revealing the final state of the molecules.

“We have strong hopes that we can do one so-called gate — that's an operation between two of these qubits, like addition, subtraction, or that sort of equivalent — in a fraction of a millisecond,” Zwierlein says. “If you look at the ratio, you could hope to do 10,000 to 100,000 gate operations in the time that we have the coherence in the sample. That has been stated as one of the requirements for a quantum computer, to have that sort of ratio of gate operations to coherence times.”

“The next great goal will be to ‘talk’ to individual molecules. Then we are really talking quantum information,” Will says. “If we can trap one molecule, we can trap two. And then we can think about implementing a ‘quantum gate operation’ — an elementary calculation — between two molecular qubits that sit next to each other,” he says.

Using an array of perhaps 1,000 such molecules, Zwierlein says, would make it possible to carry out calculations so complex that no existing computer could even begin to check the possibilities. Though he stresses that this is still an early step and that such computers could be a decade or more away, in principle such a device could quickly solve currently intractable problems such as factoring very large numbers — a process whose difficulty forms the basis of today’s best encryption systems for financial transactions.

Besides quantum computing, the new system also offers the potential for a new way of carrying out precision measurements and quantum chemistry, Zwierlein says.

“These results are truly state of the art,” says Simon Cornish, a professor of physics at Durham University in the U.K., who was not involved in this work. The findings “beautifully reveal the potential of exploiting nuclear spin states in ultracold molecules for applications in quantum information processing, as quantum memories and as a means to probe dipolar interactions and ultracold collisions in polar molecules,” he says. “I think the results constitute a major step forward in the field of ultracold molecules and will be of broad interest to the large community of researchers exploring related aspects of quantum science, coherence, quantum information, and quantum simulation.”

The team also included MIT graduate student Zoe Yan and postdoc Huanqian Loh. The work was supported by the National Science Foundation, the U.S. Air Force Office of Scientific Research, the U.S. Army Research Office, and the David and Lucile Packard Foundation.

Sunday, July 30, 2017

A Primer on Mites

Mites are small arthropods belonging to the subclass Acari (also known as Acarina) and the class Arachnida. The scientific discipline devoted to the study of ticks and mites is called acarology.

Many species live in soil as decomposers; others are predatory or parasitic, these last including the commercially important Varroa mites of honeybees, and the scabies mite of humans

Diversity and Ecology

Mites are among the most diverse and successful of all the invertebrate groups. They have exploited a wide array of habitats, and because of their small size (most are micro-animals), go largely unnoticed. Some live freely in the soil or water, but many others live as parasites on plants, animals, and some that feed on mold. Some 48,200 species of mites have been described.

Mites occupy a wide range of ecological niches. For example, Oribatida mites are important decomposers in many habitats. They eat a wide variety of material including living and dead plant and fungal material, lichens and carrion; some are predatory, though no oribatid mites are parasitic.

Many mites are parasitic on plants and animals. One family of mites Pyroglyphidae, or nest mites, live primarily in the nests of birds and animals. These mites are largely parasitic and consume blood, skin and keratin. Dust mites, which feed mostly on dead skin and hair shed from humans instead of consuming them from the organism directly, evolved from these parasitic ancestors.

Insects are sometimes infested by parasitic mites. Examples are Varroa destructor, which attaches to the body of the honey bee, and Acarapis woodi (family Tarsonemidae), which lives in the tracheae of honey bees. Hundreds of species are associated with other bees, mostly poorly described. They attach to bees in a variety of ways. For example, Trigona corvina workers have been found with mites attached to the outer face of their hind tibiae. Some are thought to be parasites, while others are beneficial symbionts. Mites also parasitize some ant species, such as Eciton burchellii.

Plant pests include the so-called spider mites (family Tetranychidae), thread-footed mites (family Tarsonemidae), and the gall mites (family Eriophyidae). Among the species that attack animals are members of the sarcoptic mange mites (family Sarcoptidae), which burrow under the skin. Demodex mites (family Demodicidae) are parasites that live in or near the hair follicles of mammals, including humans. Acari are mites, except for the three families of ticks.

The tropical species Archegozetes longisetosus is one of the strongest animals in the world, relative to its mass (100 μg): It lifts up to 1,182 times its own weight, over five times more than would be expected of such a minute animal. Mites also hold the record speed; for its length, Paratarsotomus macropalpis is the fastest animal on Earth.

Medical Significance

The majority of mite species are harmless to humans, but a few species of mites can colonize humans directly, act as vectors for disease transmission, or cause or contribute to allergenic diseases.

Mites which colonize human skin are the cause of several types of itchy skin rashes, such as grain itch, grocer's itch, and scabies. Sarcoptes scabiei is a parasitic mite responsible for scabies which is one of the three most common skin disorders in children. Demodex mites, which are common cause of mange in dogs and other domesticated animals, have also been implicated in the human skin disease rosacea, although the mechanism by which demodex contributes to the disease is unclear.

Chiggers are known primarily for their itchy bite, but they can also spread disease in some limited circumstances, such as scrub typhus. The house-mouse mite is the only known vector of the disease rickettsialpox.

House dust mites, found in warm and humid places such as beds, cause several forms of allergic diseases, including hay fever, asthma and eczema, and are known to aggravate atopic dermatitis.

Saturday, July 29, 2017

3D Images of DNA

Salk Scientists Solve Longstanding Biological Mystery of DNA Organization
Researchers image 3D genome in nucleus of living human cell for the first time

LA JOLLA—July 27, 2017 -- Stretched out, the DNA from all the cells in our body would reach Pluto. So how does each tiny cell pack a two-meter length of DNA into its nucleus, which is just one-thousandth of a millimeter across?

The answer to this daunting biological riddle is central to understanding how the three-dimensional organization of DNA in the nucleus influences our biology, from how our genome orchestrates our cellular activity to how genes are passed from parents to children.

Now, scientists at the Salk Institute and the University of California, San Diego, have for the first time provided an unprecedented view of the 3D structure of human chromatin—the combination of DNA and proteins—in the nucleus of living human cells.

In the tour de force study, described in Science on July 27, 2017, the Salk researchers identified a novel DNA dye that, when paired with advanced microscopy in a combined technology called ChromEMT, allows highly detailed visualization of chromatin structure in cells in the resting and mitotic (dividing) stages. By revealing nuclear chromatin structure in living cells, the work may help rewrite the textbook model of DNA organization and even change how we approach treatments for disease.

“One of the most intractable challenges in biology is to discover the higher-order structure of DNA in the nucleus and how is this linked to its functions in the genome,” says Salk Associate Professor Clodagh O’Shea, a Howard Hughes Medical Institute Faculty Scholar and senior author of the paper. “It is of eminent importance, for this is the biologically relevant structure of DNA that determines both gene function and activity.”

Ever since Francis Crick and James Watson determined the primary structure of DNA to be a double helix, scientists have wondered how DNA is further organized to allow its entire length to pack into the nucleus such that the cell’s copying machinery can access it at different points in the cell’s cycle of activity. X-rays and microscopy showed that the primary level of chromatin organization involves 147 bases of DNA spooling around proteins to form particles approximately 11 nanometers (nm) in diameter called nucleosomes. These nucleosome “beads on a string” are then thought to fold into discrete fibers of increasing diameter (30, 120, 320 nm etc.), until they form chromosomes. The problem is, no one has seen chromatin in these discrete intermediate sizes in cells that have not been broken apart and had their DNA harshly processed, so the textbook model of chromatin’s hierarchical higher-order organization in intact cells has remained unverified.

To overcome the problem of visualizing chromatin in an intact nucleus, O’Shea’s team screened a number of candidate dyes, eventually finding one that could be precisely manipulated with light to undergo a complex series of chemical reactions that would essentially “paint” the surface of DNA with a metal so that its local structure and 3D polymer organization could be imaged in a living cell. The team partnered with UC San Diego professor and microscopy expert Mark Ellisman, one of the paper’s coauthors, to exploit an advanced form of electron microscopy that tilts samples in an electron beam enabling their 3D structure to be reconstructed. By combining their chromatin dye with electron-microscope tomography, they created ChromEMT.

The team used ChromEMT to image and measure chromatin in resting human cells and during cell division when DNA is compacted into its most dense form—the 23 pairs of mitotic chromosomes that are the iconic image of the human genome. Surprisingly, they did not see any of the higher-order structures of the textbook model anywhere.

“The textbook model is a cartoon illustration for a reason,” says Horng Ou, a Salk research associate and the paper’s first author. “Chromatin that has been extracted from the nucleus and subjected to processing in vitro—in test tubes—may not look like chromatin in an intact cell, so it is tremendously important to be able to see it in vivo.”

What O’Shea’s team saw, in both resting and dividing cells, was chromatin whose “beads on a string” did not form any higher-order structure like the theorized 30 or 120 or 320 nanometers. Instead, it formed a semi-flexible chain, which they painstakingly measured as varying continuously along its length between just 5 and 24 nanometers, bending and flexing to achieve different levels of compaction. This suggests that it is chromatin’s packing density, and not some higher-order structure, that determines which areas of the genome are active and which are suppressed.

With their 3D microscopy reconstructions, the team was able to move through a 250 nm x 1000 nm x 1000 nm volume of chromatin’s twists and turns, and envision how a large molecule like RNA polymerase, which transcribes (copies) DNA, might be directed by chromatin’s variable packing density, like a video game aircraft flying through a series of canyons, to a particular spot in the genome. Besides potentially upending the textbook model of DNA organization, the team’s results suggest that controlling access to chromatin could be a useful approach to preventing, diagnosing and treating diseases such as cancer.

“We show that chromatin does not need to form discrete higher-order structures to fit in the nucleus,” adds O’Shea. “It’s the packing density that could change and limit the accessibility of chromatin, providing a local and global structural basis through which different combinations of DNA sequences, nucleosome variations and modifications could be integrated in the nucleus to exquisitely fine-tune the functional activity and accessibility of our genomes.”

Future work will examine whether chromatin’s structure is universal among cell types or even among organisms.

Other authors included Sébastien Phan, Thomas Deerinck and Andrea Thor of the UC San Diego.

Wednesday, July 26, 2017

Basics of Actuators

An actuator is a component of a machine that is responsible for moving or controlling a mechanism or system, for example by actuating (opening or closing) a valve; in simple terms, it is a "mover".

An actuator requires a control signal and a source of energy. The control signal is relatively low energy and may be electric voltage or current, pneumatic or hydraulic pressure, or even human power. The supplied main energy source may be electric current, hydraulic fluid pressure, or pneumatic pressure. When the control signal is received, the actuator responds by converting the energy into mechanical motion.

An actuator is the mechanism by which a control system acts upon an environment. The control system can be simple (a fixed mechanical or electronic system), software-based (e.g. a printer driver, robot control system), a human, or any other input.

History

The history of the pneumatic actuation system and the hydraulic actuation system dates to around the time of World War II (1938). It was first created by Xhiter Anckeleman (pronounced 'Ziter') who used his knowledge of engines and brake systems to come up with a new solution to ensure that the brakes on a car exert the maximum force, with the least possible wear and tear.

There are hydraulic, pneumatic, electric, thermal or magnetic, and mechanical actuators.  There now exist 3-D printed soft actuators as well.

Examples of Actuators

  • Comb drive
  • Digital micromirror device
  • Electric motor
  • Electroactive polymer
  • Hydraulic cylinder
  • Piezoelectric actuator
  • Pneumatic actuator
  • Screw jack
  • Servomechanism
  • Solenoid
  • Stepper motor
  • Shape-memory alloy
  • Thermal bimorph

Performance Metrics

Performance metrics for actuators include speed, acceleration, and force (alternatively, angular speed, angular acceleration, and torque), as well as energy efficiency and considerations such as mass, volume, operating conditions, and durability, among others.

https://en.wikipedia.org/wiki/Actuator



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Footnote

 
 

Tuesday, July 25, 2017

Terbinafine (antifungal)


Terbinafine, sold under the brand name Lamisil among others, is an antifungal medication used to treat ringworm, pityriasis versicolor, and fungal nail infections. It is either taken by mouth or applied to the skin as a cream or ointment. The cream and ointment are not effective for nail infections.

Common side effects when taken by mouth include nausea, diarrhea, headache, cough, rash, and elevated liver enzymes. Severe side effects include liver problems and allergic reactions. Use during pregnancy is not typically recommended. The cream and ointment may result in itchiness but are generally well tolerated. Terbinafine is in the allylamines family of medications. It works by decreasing the ability of fungi to make sterols.

Terbinafine was discovered in 1991. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. The wholesale cost in the developing world is about 2.20 USD for a 20 gm tube. In the United States a course of treatment costs less than 25 USD and is available over the counter.

 

Medical Uses

Terbinafine is mainly effective on the dermatophyte group of fungi.

As a cream or powder, it is used topically for superficial skin infections such as jock itch (tinea cruris), athlete's foot (tinea pedis), and other types of ringworm (tinea corporis). Terbinafine cream works in about half the time required by other antifungals.

Tablets by mouth are often prescribed for the treatment of onychomycosis, a fungal nail infection, typically by a dermatophyte or Candida species. Fungal nail infections are located deep under the nail in the cuticle to which topically applied treatments are unable to penetrate in sufficient amounts. The tablets may, rarely, cause hepatotoxicity, so patients are warned of this and may be monitored with liver function tests. Alternatives to by mouth administration have been studied.

Terbinafine hydrochloride may induce or exacerbate subacute cutaneous lupus erythematosus. Persons with lupus erythematosus should first discuss possible risks with their doctor before initiation of therapy.

Monday, July 24, 2017

A Primer on Contentment


Contentment is a mental or emotional state of satisfaction maybe drawn from being at ease in one's situation, body and mind. Colloquially speaking, contentment could be a state of having accepted one's situation and is a milder and more tentative form of happiness.


Peace and Contentment
By Eduard von Grutzner, 1897

Contentment and the pursuit of contentment are possibly a central thread through many philosophical or religious schools across diverse cultures, times and geographies. Siddharta might have said "Health is the most precious gain and contentment the greatest wealth". John Stuart Mill, centuries later, would write "I have learned to seek my happiness by limiting my desires, rather than in attempting to satisfy them." Marcus Aurelius wrote "Live with the gods. And he who does so constantly shows them that his soul is satisfied with what is assigned to them." Hebrews 13:5 reads "Keep your lives free from the love of money and be content with what you have, because God has said, 'Never will I leave you; never will I forsake you.'" Chinese philosopher Zhuang Zhou once wrote in the 3rd century BCE (hypothetically) "A gentleman who profoundly penetrates all things and is in harmony with their transformations will be contented with whatever time may bring. He follows the course of nature in whatever situation he may be."

The literature seems to generally agree that contentment is maybe a state ideally reached through being happy with what a person has, as opposed to achieving one's larger ambitions, as Socrates described by probably saying "He who is not contented with what he has, would not be contented with what he would like to have." That said, there may be a number of elements of achievement that may make finding a state of personal contentment easier: a strong family unit, a strong local community, and satisfaction of life's basic needs as perhaps expressed in Maslow's hierarchy of needs. In general, the more needs in Maslow's hierarchy are achieved, the more easily one might achieve contentment.

Personality

Through factor analysis, personality can be narrowed down according to the five factor model, which holds that there are five aspects of heritable personality traits: openness to experience, conscientiousness, extraversion, agreeableness, and neuroticism. Research has shown that personality is 50% heritable, but not always. There are two aspects of personality which are related to happiness. There is a strong relationship between extraversion and happiness, in that the more extraverted a person is (or behaves) the more happy he/she will be. The other aspect of personality which has a strong relationship to happiness is the genetic predisposition to neuroticism. The more neurotic (emotionally unstable) a person is, the more likely he/she is to be unhappy.

Laughter

Laughter is synonymous with happiness. A proposal is made here that when a line of thought (e.g. joke) or sensation (e.g. tickling) is not expected by one's psychological or physiological order respectively, it triggers a certain chaos and temporary breakdown of that order. The innate Contentment intrinsic to the person then breaks through this temporal breach to express itself in happy laughter.

Laughter has been used as a health therapy for many years such as in some hospitals through the showing of TV comedies for patients. Laughter clubs have also been formed in India and some Asian countries to promote laughter as a form of health-enhancement through regular meet-ups.

Sunday, July 23, 2017

World's Most Dangerous Snakes

Introduction

The most dangerous snakes in the world tend to be sea snakes around Australia, the Coral Sea, Indonesia and adjacent land areas.  These are even worse than mambas, cobras and rattlesnakes.

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Snake
Region
Sea snake
Australia
Inland Taipan
Coral Sea, Arafura Sea, Timor Sea and Indian Ocean
Eastern brown snake
Australia, Papua New Guinea, Indonesia
Tropical oceanic waters
Gulf of Siam, Strait of Taiwan, Coral sea islands, and other places
Australia
Mainland China, Taiwan, Vietnam, Laos, Burma
eastern coast of the Malay Peninsula and Brunei, and in Halmahera, Indonesia
Australia
Western Australian Tiger snake
Australia
Tropical Indo-Pacific