Saturday, October 24, 2015

Game Show History

A game show is a type of radio, television, or internet programming genre in which contestants, television personalities or celebrities, sometimes as part of a team, play a game which involves answering questions or solving puzzles usually for money and/or prizes. Alternatively, a gameshow can be a demonstrative program about a game (while usually retaining the spirit of a rewards ceremony). In the former, contestants may be invited from a pool of public applicants. On some shows, contestants compete against other players or another team, while other shows involve contestants playing alone for a good outcome or a high score. Game shows often reward players with prizes such as cash, trips and goods and services provided by the show's sponsor prize suppliers, who in turn usually do so for the purposes of product placement.

Television game shows descended from similar programs on radio. The very first television game show, Spelling Bee, was broadcast in 1938. Truth or Consequences was the first game show to air on commercially licensed television. Its first episode aired in 1941 as an experimental broadcast.

Over the course of the 1950s, as television began to pervade the popular culture, game shows quickly became a fixture. Daytime game shows would be played for lower stakes to target stay-at-home housewives. Higher-stakes programs would air in primetime. During the late 1950s, high-stakes games such as Twenty One and The $64,000 Question began a rapid rise in popularity. However, the rise of quiz shows proved to be short-lived. In 1959, many of the higher stakes game shows were discovered to be rigged. Ratings declines led to most of the prime time games being canceled.

An early variant of the game show, the panel game, survived the quiz show scandals. On shows like What's My Line?, I've Got A Secret and To Tell The Truth, panels of celebrities would interview a guest in an effort to determine some fact about them; in others, celebrities would answer questions. Panel games had success in primetime until the late 1960s, when they were collectively dropped from television because of their perceived “low budget” nature. Panel games made a comeback in American daytime television (where the lower budgets were tolerated) in the 1970s through comedy-driven shows such as Match Game and Hollywood Squares. In the UK, where commercial demographic pressures were not as prominent, panel shows were kept in primetime and have continued to thrive; they have transformed into showcases for the nation's top stand-up comedians on shows such as Have I Got News For You, Would I Lie to You?, Mock The Week, QI and 8 out of 10 Cats, all of which put a heavy emphasis on comedy, leaving the points as mere formalities. The focus on quick-witted comedians has resulted in strong ratings, which, combined with low costs of production, have only spurred growth in the UK panel show phenomenon.

Game shows remained a fixture of US daytime television through the 1960s after the quiz show scandals. Lower-stakes games made a slight comeback in daytime in the early 1960s; examples include Jeopardy! which began in 1964 and the original version of The Match Game first aired in 1962. Let's Make a Deal began in 1963 and the 1960s also marked the debut of Hollywood Squares, Password, The Dating Game and The Newlywed Game.

Though CBS gave up on daytime game shows in 1968, the other networks did not follow suit. Color television was introduced to the game show genre in the late 1960s on all three networks. The 1970s saw a renaissance of the game show as new games and massive upgrades to existing games made debuts on the major networks. The New Price Is Right, an update of the 1950s-era game show The Price Is Right, debuted in 1972 and marked CBS's return to the game show format in its effort to draw wealthier, suburban viewers. The Match Game became "Big Money" Match Game 73, which proved popular enough to prompt a spin-off, Family Feud, on ABC in 1976. The $10,000 Pyramid and its numerous higher-stakes derivatives also debuted in 1973, while the 1970s also saw the return of formerly disgraced producer and host Jack Barry, who debuted The Joker's Wild and a clean version of the previously rigged Tic-Tac-Dough in the 1970s. Wheel of Fortune debuted on NBC in 1975. The Prime Time Access Rule, which took effect in 1971, barred networks from broadcasting in the 7-8 p.m. time slot immediately preceding prime time, opening up time slots for syndicated programming. Most of the syndicated programs were "nighttime" adaptations of network daytime game shows; these game shows originally aired once a week, but by the late 1970s and early 1980s most of the games had transitioned to five days a week.

Game shows were the lowest priority of television networks, and were rotated out every thirteen weeks if unsuccessful. Most tapes were destroyed until the early 1980s. Over the course of the late 1980s and early 1990s as fewer new hits were produced, game shows lost their permanent place in the daytime lineup. ABC gave up on game shows in 1991. NBC also lasted until 1991, but attempted to bring them back in 1993 before cancelling its game show block again in 1994. CBS phased out most of their game shows, except for The Price Is Right, by 1993. To the benefit of the genre, the moves of Wheel of Fortune and a modernized revival of Jeopardy! to syndication in 1983 and 1984, respectively, was and remains highly successful; the two are, to this day, fixtures in the prime time "access period".

Friday, October 23, 2015

Hurricane Patricia -- Category 5

Hurricane Patricia (Spanish pronunciation: [paˈtɾisia]) is an active, powerful but weakening tropical cyclone impacting Western Mexico. It was recently the most intense tropical cyclone ever observed in the Western Hemisphere in terms of barometric pressure and the strongest globally in terms of reliably measured maximum sustained winds. Originating from a sprawling disturbance near the Gulf of Tehuantepec in mid-October 2015, Patricia was first classified a tropical depression on October 20.  Initial development was slow, with only modest strengthening within the first day of its classification. The system later became a tropical storm and was named Patricia, the twenty-fourth named storm of the 2015 Pacific hurricane season.  Exceptional environmental conditions fueled explosive intensification on October 22. A well-defined eye developed within an intense central dense overcast and Patricia grew from a tropical storm to a Category 5 hurricane in just 24 hours. The rate of intensification was greater than that of any other Pacific hurricane on record in the satellite-era (1960s–present)—only Hurricane Linda in 1997 strengthened at a similar rate. The precursor to Patricia produced widespread, flooding rains in Central America. Hundreds of thousands of people were directly affected by the storm, mostly in Guatemala. At least six fatalities have been attributed to the event: four in El Salvador, one in Guatemala, and one in Nicaragua.

                                                        Hurricane Patricia seen from the
                                                        International Space Station on
                                                        October 23, 2015

Late on October 23, Patricia became only the second Pacific hurricane on record to make landfall as a Category 5 hurricane, after the 1959 Mexico hurricane, and the first to strike either coast of Mexico as a Category 5 hurricane since Dean in 2007.

Current storm status
Category 5 hurricane (1-min mean)
As of:
7:00 p.m. CDT October 23 (00:00 UTC October 24)
Location:
About 50 mi (85 km) WNW of Manzanillo, MX
About 135 mi (220 km) SW of Guadalajara, MX
Winds:
140 kt (160 mph; 260 km/h) sustained (1-min mean)
gusting to 175 kt (200 mph; 325 km/h)
Pressure:
900 mbar (27.29 inHg)
Movement:
NNE at 12 kt (14 mph; 22 km/h)

Thursday, October 22, 2015

Angry TV Rant about USA Corruption

A very reputable CPA friend of mine sent me a Facebook video today about how corrupt Washington is and how it has become impossible for the US government to achieve stable economic growth because the nation is being bled dry by regulation and international banking.  A very lively televised discussion of this issue can be seen at this link:

Wednesday, October 21, 2015

Flexible Artificial Corneas

Is the End in Sight for Reading Glasses?
University of Leeds, October 15, 2015
A University of Leeds researcher is developing a new eye lens, made from the same material found in smartphone and TV screens, which could restore long-sightedness in older people.

As people age, their lenses lose flexibility and elasticity. This leads to a condition known as presbyopia, common in people over 45 years old, and can require optical aids, such as reading glasses.

Devesh Mistry, a postgraduate research student in the School of Physics and Astronomy, is now working with liquid crystal to create a truly adjustable artificial lens.

He said: “As we get older, the lens in our eye stiffens, when the muscles in the eye contract they can no longer shape the lens to bring close objects into focus.”

“Using liquid crystals, which we probably know better as the material used in the screens of TVs and smartphones, lenses would adjust and focus automatically, depending on the eye muscles’ movement.”

Using these liquid crystal-based materials, Devesh’s research is developing synthetic replacements for the diseased lens in the eye - a new generation of lenses and intra-ocular lens implants to rejuvenate sight.

Devesh is currently researching and developing the lens in the lab and aims to have a prototype ready by the end of his doctorate in 2018.

Within a decade, the research could see the new lens being implanted into eyes in a quick and straightforward surgical procedure under local anaesthetic.

Eye surgeons would make an incision in the cornea and use ultrasound to break down the old lens. The liquid crystal lens would then be inserted, restoring clear vision.

The lens could also have application in tackling cataracts - the clouding of natural lenses - which affect many people in later life and which can seriously affect vision. A common treatment is to remove and replace the natural lens.

“Liquid crystals are a very under-rated phase of matter,” Devesh told The Times, “Everybody’s happy with solids, liquids and gases and the phases of matter, but liquid crystals lie between crystalline solids and liquids. They have an ordered structure like a crystal, but they can also flow like a liquid and respond to stimuli.”

Devesh is working in collaboration with the Eurolens Research at the University of Manchester and with UltraVision CLPL, a specialist contact lenses manufacturer headed up by two University of Leeds alumni.

His research builds upon previous work by the same collaborators, who developed a prototype contact lens with an electrically-controllable focus using liquid crystals.

The first commercially-available liquid crystal lenses could be on sale between six and ten years’ time.

The research is funded by the Engineering and Physical Sciences Research Council (EPSRC) and Ultravision CLPL.

Devesh was recently awarded an Industrial Fellowship from the Royal Commission for the Exhibition of 1851, which awards a range of fellowships and grants to support science and engineering research and industrial education across the UK.

Professor Helen Gleeson, Head of the School of Physics and Astronomy at the University of Leeds and one of Devesh’s academic supervisors, said: “I'm thrilled that Devesh has won the RC1851 Industrial Fellowship. This will support an excellent student working on an exciting project that involves optometry, physics and engineering, helping us to take our research ideas towards a practical device.”

The Industrial Fellowship is designed to support innovative technology with commercial potential, ideally leading to a patent, while completing a PhD or EngD.

Tuesday, October 20, 2015

Better Root Canal Procedures

Nanodiamonds Might Prevent
Tooth Loss after Root Canals
UCLA Dentistry research finds that the tiny particles strengthen the compound used to fill teeth and ward off infection
Brianna Aldrich, UCLA, October 16, 2015

People undergoing root canals may have gained a powerful, if tiny, new ally. Researchers from the UCLA School of Dentistry have found that using nanodiamonds to fortify a material used in the procedure could significantly improve outcomes for patients. 

A paper on their research is published in the current issue of the peer-reviewed journal ACS Nano.

Nanodiamonds are tiny particles formed as byproducts of diamond refining and mining. Thousands of times smaller than the width of a human hair, they have been widely explored for use in dentistry, cancer therapy, imaging and regenerative medicine, among other applications.

Each year, more than 15 million root canal procedures are performed in the United States. Dentists’ goal is to save their patients’ teeth from infected dental “pulp” — the part of the tooth that includes blood vessels and nerve tissue. During a root canal, inflamed dental pulp is removed and the empty space is then filled in with a polymer called gutta percha, which is used in part because it does not react within the body. But some root canals don’t entirely remove the infection, and residual infection after root canals can lead to tooth loss.

In addition, traditional gutta percha has certain shortcomings, including a limited capacity to ward off infection and less-than-optimal rigidity.

To overcome those issues, the UCLA team developed and tested two types of reinforced gutta percha: One strengthened with nanodiamonds and another strengthened with nanodiamonds that had been pre-loaded with antibiotics.

To evaluate the first type, Sue Vin Kim and Adelheid Nerisa Limansubroto, study co-authors who are UCLA Dentistry students, filled actual teeth from human patients. Using conventional radiography and micro-computed tomography, or micro-CT, they showed that the nanodiamond-enhanced gutta percha could be used to fill the tooth. Like the traditional formulation, the nanodiamond-enhanced compound did leave small gaps in the canal — where harmful bacteria could grow — but the CT imaging showed that the enhanced material filled the space just as effectively as traditional gutta percha.

“Validating this novel material in teeth extracted from patients serves as a strong foundation for the potential translation of nanodiamond-reinforced gutta percha toward clinical testing,” said Dean Ho, a senior author of the study and a professor of oral biology and medicine and co-director of UCLA Dentistry’s Jane and Jerry Weintraub Center for Reconstructive Biotechnology.

In the research’s second phase, the scientists tested nanodiamonds that had been loaded with amoxicillin, a broad-spectrum antibiotic used to combat infection. The drug-reinforced nanodiamonds, when combined with the gutta percha, effectively prevented bacteria growth.

“The nanodiamond-enhanced gutta percha combines many desirable properties into a single platform, including vastly improved mechanical characteristics and the ability to combat bacterial infection following a root canal,” said Dong-Keun Lee, a postdoctoral scholar in Ho’s lab.

The study involved UCLA researchers with expertise in a wide range of disciplines — materials science, nanotechnology, drug delivery, toxicology, oral radiology, endodontics, microbiology and other fields.

“Through their ingenuity and collaboration, Professor Ho’s team is poised to transform the way that dentistry is practiced,” said Dr. No-Hee Park, dean of UCLA Dentistry and a co-author of the study.

During the next two years, the team plans optimize the formulation of the nanodiamond-reinforced gutta percha and begin clinical trials at UCLA.

Ho is also a professor of bioengineering and member of the UCLA Jonsson Comprehensive Cancer Center and the California NanoSystems Institute at UCLA. Other authors of the study were Albert Yen of the UCLA department of bioengineering and UCLA Dentistry; and Akrivoula Soundia, Yong Kim, Wenyuan Shi, Dr. Christine Hong, Dr. Sotirios Tetradis, Dr. Cun-Yu Wang and Dr. Mo Kang, all of UCLA Dentistry.

Monday, October 19, 2015

Anti-Cancer Protein?

Protein Found in Malaria Could Help Stop Cancer
Malarial protein binds to a sugar molecule found in many types of cancer, enabling anti-cancer drugs to target tumors

PHOENIX, Ariz. - Oct. 16, 2015 - Researchers at the Translational Genomics Research Institute (TGen) joined an international team of scientists in discovering how a protein from malaria could some day help stop cancer.

Collaborators at the University of Copenhagen, while exploring why pregnant women are particularly susceptible to malaria, found that the mosquito-borne parasite that causes malaria also produces a protein that binds to a particular type of sugar molecule in the placenta.

Researchers found that the same type of sugar molecule also is present in many types of cancer.

Scientists at the University of British Columbia, Vancouver Coastal Health and the BC Cancer Agency, working with those from Copenhagen, realized that the sugar molecule - oncofetal chondroitin sulfate - could be a target for anti-cancer drugs, and that the malarial protein, called VAR2CSA, could provide the tool for carrying such drugs to tumors.

TGen scientists were called in to help test the theory.

"Based on our clinical data, we helped validate that this could be applied to melanoma and lung cancers," said Dr. Nhan Tran, an Associate Professor in TGen's Cancer and Cell Biology Division, and one of the authors of the study. "This specific type of developmental protein - oncofetal chondroitin sulfate - is expressed in the placenta, and is also expressed in lung cancer and in melanoma."

Malaria uses VAR2CSA to embed itself in the placenta - hiding itself from the immune system - by binding to oncofetal chondroitin sulfate.

In laboratory experiments, researchers found that if they used the malarial protein, VAR2CSA, and attached an anti-cancer drug to it, it would bind with the oncofetal protein in the cancer, delivering the drug to the tumor.

The results of the scientific study - Targeting Human Cancer by a Glycosaminoglycan Binding Malaria Protein - were published Oct. 12 in the journal Cancer Cell.

"Scientists have spent decades trying to find biochemical similarities between placenta tissue and cancer, but we just didn't have the technology to find it," said project leader Mads Daugaard, an assistant professor of urologic science at UBC and a senior research scientist at the Vancouver Prostate Centre, part of the Vancouver Coastal Health Research Institute. "When my colleagues discovered how malaria uses VAR2CSA to embed itself in the placenta, we immediately saw its potential to deliver cancer drugs in a precise, controlled way to tumors."

"This is an extraordinary finding that paves the way for targeting sugar molecules in pediatric and adulthood human cancer, and our groups are vigorously pursuing this possibility together," said Poul Sorensen, a UBC professor of Pathology and Laboratory Medicine and distinguished scientist with the BC Cancer Agency and co-senior investigator on the study.

"There is some irony that a disease as destructive as malaria might be exploited to treat another dreaded disease," said Ali Salanti, a professor of immunology and microbiology at the Centre for Medical Parasitology, at University of Copenhagen.

Two companies, Vancouver-based Kairos Therapeutics and Copenhagen-based VAR2 Pharmaceuticals, are developing the compound for clinical trials in humans, which will take another three to four years.


Sunday, October 18, 2015

Arkady Shevchenko

Arkady Nikolayevich Shevchenko (Ukrainian: Аркадій Миколайович Шевченко October 11, 1930 – February 28, 1998), a Soviet diplomat, was the highest-ranking Soviet official to defect to the West.

Shevchenko joined the diplomatic service of the Soviet Union as a young man and rose through the ranks of the Soviet Foreign Ministry, becoming advisor to Andre Gromyko, Minister for Foreign Affairs. In 1973 he was appointed Under Secretary General (USG) of the United Nations. During his assignment at the UN headquarters in New York City Shevchenko began passing Soviet secrets to the CIA. In 1978 he cut his ties to the Soviet Union and defected to the United States.

Foreign Service Career

In 1956 Shevchenko joined the Soviet foreign service as an attaché and was assigned to the OMO (Russian: Отдел Международных Организаций Министерства Иностранных Дел СССР, Department of International Organizations at the Ministry for Foreign Affairs of the USSR), a branch of the Foreign Ministry dealing with the United Nations and NGOs. In 1958 he was sent to New York City on a three month assignment to represent the Soviet Union at the annual United Nations General Assembly as a disarmament specialist.

Shevchenko attended the 1962 Geneva Committee on Disarmament Negotiations as a member of the Soviet delegation. The next year he accepted an assignment as Chief of the Soviet Mission's Security Council and Political Affairs Division at the United Nations. This being a permanent posting, his family accompanied him to NYC. He continued in this post until 1970 when he was appointed advisor to Andrei Gromyko. His duties covered a broad range of Soviet foreign policy initiatives.

In 1973 Shevchenko was promoted and became an Under Secretary General of the United Nations. Although he was nominally employed by the United Nations and owed his allegiance to that international organization, in practice he was expected to support and promote the aims and policies of the Soviet Union. He eventually became resentful of the restrictions that his Soviet superiors subjected him to which prevented him from carrying out his duties as an Under Secretary in an unbiased manner.

Espionage and Defection

The early 1970s were a time of détente between the Eastern Bloc and NATO nations. SALT I, the Anti-Ballistic Missile Treaty, the Helsinki Accords, and other international agreements were negotiated during this time. According to Shevchenko's memoirs, he became increasingly disillusioned with Soviet compliance with these international agreements. He had immediate access to the inner workings of the Soviet foreign policy establishment and felt that the Soviet government was cheating on the intent of the agreements for short term political gain, ultimately to its own disadvantage. He also came to believe that Soviet internal economic policies and insistence on hard-line Communist centralization of power were depriving the Russian people of their freedom and ability to better themselves and their country. His long years of exposure to Western democracies convinced him that the Soviets were "taking the wrong path", economically and politically. He briefly considered resigning his position with the UN and returning to the Soviet Union in an attempt to change the system from within, but he soon came to the realization that it would have been an impossible task. He had neither the power nor the influence to effect any significant change.

By 1975 he had decided to defect. He made contact with the United States Central Intelligence Agency seeking political asylum. But the CIA pressured him to continue at his post with the United Nations and to supply them with inside information on Soviet political plans. Although fearful of the consequences if he were to be found out by the KGB, he reluctantly agreed. For the next three years, he became in effect a "triple agent". Outwardly, a dedicated servant of the United Nations but covertly promoting the political aims of the USSR and, on top of that, secretly reporting the Soviets’ hidden political agenda to the CIA.

In early 1978 he became aware of increased KGB surveillance of his movements. Then suddenly in March he received a cable from Moscow summoning him to return to the Soviet Union for "consultations". Suspicious of the demand and realizing that if he flew to Moscow he may never be permitted to return to his UN duties or even leave the Soviet Union, he called his CIA contact and demanded that they fulfill their promise of political asylum.

Aftermath

Unfortunately for Shevchenko, his wife Leongina, who up until that point knew nothing of his plans to defect, refused to accompany him. She was immediately whisked back to Moscow where she died mysteriously, supposedly a suicide, less than two months later. In the Soviet Union Shevchenko was tried in absentia and sentenced to death.

From 1978 until his death twenty years later in Bethesda, Maryland, Shevchenko lived in the United States and supported himself with written contributions to various publications and on the lecture circuit. In 1985 he published his autobiography, "Breaking With Moscow". In his book, he described Soviet Russia as, among other things, a gangster economy where the KGB intelligence service played a prominent role.

Shevchenko died of cirrhosis of the liver on February 28, 1998, and was buried in Washington, DC.