Friday, August 7, 2020

Problem: Computers Driving Cars


AAA: Partially automated driving systems don’t always work

By TOM KRISHER

“DETROIT (AP) — August 6, 2020 -- Two tests by AAA during the past two years show that partially automated driving systems don’t always function properly, so the auto club is recommending that car companies limit their use.”

More at: https://apnews.com/addf53726301c6bbd5a48b4f361b64cd

Thursday, August 6, 2020

Virus Research Pledge by PhRMA

Biopharmaceutical Commitment Against COVID-19

In these unprecedented times, America’s biopharmaceutical companies are coming together to achieve one shared goal: the eradication of COVID-19. The decades-long investments we have made in new technology, research and treatments have prepared us to act swiftly:

• We are rapidly screening our vast global libraries of medicines to identify potential treatments and have numerous clinical trials underway to test new and existing therapies

• We are dedicating our top scientists and using our investments in new technologies to speed the development of safe and effective vaccines

• We are sharing the learnings from clinical trials in real time with governments and other companies to advance the development of additional therapies

• We are expanding our unique manufacturing capabilities and sharing available capacity to ramp up production once a successful medicine or vaccine is developed

• We are collaborating with government agencies, hospitals, doctors and others to donate supplies and medicines to help those affected around the world

• We are working with governments and insurers to ensure that when new treatments and vaccines are approved they will be available and affordable for patients

• We are coordinating with the governments and diagnostic partners to increase COVID-19 testing capability and capacity

• We are protecting the integrity of the pharmaceutical supply chain and keeping our plants open to maintain a steady supply of medicines for patients

• We are providing financial support and in-kind donations to organizations and patients around the globe

• We are working hard to protect our workforce and the communities where we live and work, having employees working from home whenever possible and keeping our salesforces out of hospitals and physicians’ offices

• We are remaining steadfast in our commitment to research and development of new medicines to prevent, treat and cure disease in all its forms, not just COVID-19 OUR COMMITMENT TO BEAT CORONAVIRUS

Learn more at PhRMA.org/coronavirus and bio.org/coronavirus We all have unique roles to play and are confident that together we can be successful. And we won’t rest until we are.

https://phrma.org/-/media/Project/PhRMA/PhRMA-Org/PhRMA-Org/PDF/G-I/Industry-Principles-on-Coronavirus-March-17.pdf


Wednesday, August 5, 2020

The Wisdom of Living Calmly

Why a Year of No Dating Was the Best Thing I Ever Did for Myself.

By Jessica Kaufman in The Elephant Journal

December 5, 2016 -- Several years ago, when I was living in NYC, I met a bunch of women who were doing this “year of no dating” thing.

No sex, no crushes, no seduction—just showing up in the world as a platonic sister to all. No hopeful texting, no “will he kiss me or won’t he,” no fantasizing about anyone sparkly and new.

At first, I was horrified to hear that people were doing this on purpose. Why deny yourself the life-changing power and magic of falling in love? The prospect of intentionally abstaining from romance was as inconceivable to me as sobriety is to an active alcoholic. Love is what got me through! It seemed like agreeing to live life without anything nice—like back rubs or vacation.

Several years ago, when I was living in NYC, I met a bunch of women who were doing this “year of no dating” thing.

No sex, no crushes, no seduction—just showing up in the world as a platonic sister to all. No hopeful texting, no “will he kiss me or won’t he,” no fantasizing about anyone sparkly and new.

At first, I was horrified to hear that people were doing this on purpose. Why deny yourself the life-changing power and magic of falling in love? The prospect of intentionally abstaining from romance was as inconceivable to me as sobriety is to an active alcoholic. Love is what got me through! It seemed like agreeing to live life without anything nice—like back rubs or vacation.

I talked to these gorgeous, capable, satisfied single women, and listened to their stories. Before I knew what I had decided to, I’d set a date to stop dating.

That meant calling it off with the brooding blonde man from Boston who I started seeing in order to numb the pain of my recent divorce. It meant not filling my self-worth meter with the affections of someone new. It meant showing up to social gatherings committed to going home alone.

Every night. For a year.

Something inside me screamed and cried and seriously doubted that I could make it and that’s when it hit me—I had been using love as a substitute for self-worth.

Why be alone if it meant doubting I was worthy of someone’s love, anyone’s love? Why should I have to face that?

I hadn’t been sans-crush since middle school. I’d been bookending relationships since high school. My heart was like a grocery list: I need to get Sean. Nope, Tommy. Nope, Elisha. Nope, Jimmy. Nope, Dave. Nope, Allison.

Relationships fueled me to the point that I didn’t know what else I could run on. And I didn’t know any of this until I put them all down.

When I quit dating, I experienced serious withdrawal. First, from Boston guy, then from my ex-husband, then from the affair I’d had at the end of my marriage. Like layers of an onion, back and back and back, until one day I felt cleaner than I’d ever felt before. I felt fresh, light, open, new, and me. Those ghosts just weren’t with me anymore.

I felt myself in a fullness of presence that, for whatever reason, I hadn’t been able to feel while I was pushing around a shopping cart full of romantic yearning and unprocessed relationships. Taking serious time off allowed me to pick everything up out of that cart one at a time, look at it for what it was, and put it back.

I didn’t just walk away from my cart for a new one, or burn down the store. I did the work in a way that you can only really do when you’re single for a long stretch of time.

An amazing thing happened during that time—I came to realize that I could access the gifts of “a year of no dating” any time I needed it. While I don’t think everyone needs to take a whole year each and every time, I do recognize how valuable it is to take some time. A significant amount of time, meaning: you have to look at what’s in your cart.

What have you been pushing around? Or has it been pushing you? Are you tempted to abandon the cart, burn down the store, or (what I believe my most recent ex is doing) just add another beautiful, shining, heart-expanding item to the pile?

Don’t get me wrong; relationships are great. They are powerful teachers and offer us so much deep joy and growth and understanding. But until you’ve really known what it is to find that joy, growth, and understanding without the catalyst of a new relationship, I think that part of you will always remain unknown to yourself. Like a forgotten drawer or corner, it piles up with the detritus of what you haven’t unpacked, and you—not to mention your future relationships—will have to navigate around it forever.

My last boyfriend and I broke up five months ago, and I’m healing. My work now is to be single again. For a while. I need time and space to make sure that I continue rebuilding my life without the influence of my next “big relationship.” I need to get my new business off the ground. I need to continue to work the steps in my recovery program. I need to finish nursing the wounds my last relationship left in me, and I need time to further understand why I said yes to that relationship when both of us knew it was going to be a struggle. Most of all, I need time—real, seasons-passing time—to get used to my life’s rhythms as an unpartnered person (though I might not choose to be totally celibate this time around!).

When I meet my next serious partner, I want to be as free and healed-up as possible, to have had time to process not just the breakup with my most recent ex, but the overarching patterns in my series of adult relationships. I owe that to myself, and my next partner gets it as a side benefit of choosing someone as wise and mature as me, ha!

It’s been difficult to watch my last two exes move right into their next big things, but no one can be the arbiter of how other people are doing it. I’m sure it feels as right to them to move on quickly as it does to me to slow that train to a halt.

I believe there’s power and strength in solo time, and I’m amazed that it took me so long to figure that out.

So if you’re afraid, or curious, or willing, take your time. Try it out. Say no for now, if even part of you thinks that you could use a break.

Find your wholeness before you find your next love. It will serve you for the rest of your life.

https://www.elephantjournal.com/2016/12/why-a-year-of-no-dating-was-the-best-thing-i-ever-did-for-myself/?fbclid=IwAR0u4zbaWVqtb9xw-nCe4TnRbR7fuonvuKkuJ71ULgxOYtSVKVUCbppw5mA


Tuesday, August 4, 2020

An Invincible Virus Exists

There is a phage that resists all forms of CRISPR.  It has been studied for several years in San Francisco with a thoroughness that has uncovered surprising insights.  Ed Yong, writing for the December 11, 2019, The Atlantic, explains this research here:

https://www.theatlantic.com/science/archive/2019/12/startling-secret-invincible-virus/603412/


Monday, August 3, 2020

Oak Ridge Supercomputer Sorts Virus Code

Mark Anderson has written an article that was included in the IEEE Spectrum on August 2, 2020.  It discussed massive computer power studying the genetic mature of the COVID-19 and its effects on patients.

“A supercomputer-powered genetic study of COVID-19 patients has spawned a possible breakthrough into how the novel coronavirus causes disease—and points toward new potential therapies to treat its worst symptoms.

“The genetic data mining research uncovered a common pattern of gene activity in the lungs of symptomatic COVID-19 patients, which when compared to gene activity in healthy control populations revealed a mechanism that appears to be a key weapon in the coronavirus’s arsenal.

“The good news is there are already drugs—a few of which are already FDA-approved—aimed at some of these very same pathologies.”

Much more at:  https://spectrum.ieee.org/the-human-os/computing/hardware/has-the-summit-supercomputer-cracked-the-covid-code


Sunday, August 2, 2020

Breakthrough in Wearable Monitors

New Electronics Platform Provides Better Data for Personalized Care

By Jeannie Kever

University of Houston – July 30, 2020 -- A team of researchers led by Cunjiang Yu, Bill D. Cook Associate Professor of Mechanical Engineering at the University of Houston, has developed a new form of electronics known as “drawn-on-skin electronics,” allowing multifunctional sensors and circuits to be drawn on the skin with an ink pen.

The advance, the researchers report in Nature Communications, allows for the collection of more precise, motion artifact-free health data, solving the long-standing problem of collecting precise biological data through a wearable device when the subject is in motion.

The imprecision may not be important when your FitBit registers 4,000 steps instead of 4,200, but sensors designed to check heart function, temperature and other physical signals must be accurate if they are to be used for diagnostics and treatment.

The drawn-on-skin electronics are able to seamlessly collect data, regardless of the wearer’s movements.  

They also offer other advantages, including simple fabrication techniques that don’t require dedicated equipment.

“It is applied like you would use a pen to write on a piece of paper,” said Yu. “We prepare several electronic materials and then use pens to dispense them. Coming out, it is liquid. But like ink on paper, it dries very quickly.”

Wearable bioelectronics – in the form of soft, flexible patches attached to the skin – have become an important way to monitor, prevent and treat illness and injury by tracking physiological information from the wearer. But even the most flexible wearables are limited by motion artifacts, or the difficulty that arises in collecting data when the sensor doesn’t move precisely with the skin.

The drawn-on-skin electronics can be customized to collect different types of information, and Yu said it is expected to be especially useful in situations where it’s not possible to access sophisticated equipment, including on a battleground.

The electronics are able to track muscle signals, heart rate, temperature and skin hydration, among other physical data, he said. The researchers also reported that the drawn-on-skin electronics have demonstrated the ability to accelerate healing of wounds.

In addition to Yu, researchers involved in the project include Faheem Ershad, Anish Thukral, Phillip Comeaux, Yuntao Lu, Hyunseok Shim, Kyoseung Sim, Nam-In Kim, Zhoulyu Rao, Ross Guevara, Luis Contreras, Fengjiao Pan, Yongcao Zhang, Ying-Shi Guan, Pinyi Yang, Xu Wang and Peng Wang, all from the University of Houston, and Jiping Yue and Xiaoyang Wu from the University of Chicago.

The drawn-on-skin electronics are actually comprised of three inks, serving as a conductor, semiconductor and dielectric.

“Electronic inks, including conductors, semiconductors, and dielectrics, are drawn on-demand in a freeform manner to develop devices, such as transistors, strain sensors, temperature sensors, heaters, skin hydration sensors, and electrophysiological sensors,” the researchers wrote.

This research is supported by the Office of Naval Research and National Institutes of Health.

https://uh.edu/news-events/stories/july-2020/07302020yu-liquid-electronics.php


Saturday, August 1, 2020

A Longer and Healthier Life

12 Ways You Can Drastically Cut Your Dementia Risk

By Alice Klein, New Scientist

July 30, 2020 -- Almost half of all dementia cases could potentially be prevented or delayed by adopting 12 health measures, a major review has found.

The review identified the biggest known risk factors for dementia as 

·         Smoking

·         Excess Alcohol Consumption

·         High Blood Pressure

·         Obesity

·         Diabetes

·         Head Injury

·         Depression

·         Hearing Loss

·         Exposure to Air Pollution

·         Lack of Exercise

·         Lack of Education

·         Lack of Social Contact

Minimizing these 12 risks could potentially prevent or delay up to 40 per cent of dementia cases globally, according to the review of the latest evidence by 28 leading dementia experts from around the world.

“People who have family members with dementia often ask me, ‘Is there anything I can do to prevent myself from getting it?’,” says David Ames at the University of Melbourne in Australia, who was one of the authors of the review. “There are certainly some things you can do that might make a difference.”

For example, the review finds that individuals can partially protect themselves by not smoking, drinking less than 21 units of alcohol per week, maintaining a systolic blood pressure of less than 130 mmHg, avoiding activities that could lead to head injuries, using hearing aids if needed, eating a healthy diet, and exercising and socialising regularly.

Even older people can delay or possibly even prevent dementia by taking steps to improve their lifestyles, says Ames. “It’s never too early and it’s never too late to think about reducing your risk,” he says.

In addition to making recommendations for individuals, the review calls on governments to protect their populations from dementia by providing primary and secondary education for all children, improving air quality, promoting healthy behaviours, and discouraging smoking and heavy drinking.

In some higher-income countries, including the UK, US and France, dementia rates in older people have fallen in recent decades, possibly due to improvements in education, nutrition and health care. This suggests that preventative health measures can have an impact on dementia, in the same way they have helped to reduce rates of lung cancer and deaths from heart disease in many higher-income countries, says Ames.

Two-thirds of dementia cases currently occur in lower-income and middle-income countries, where education is often less accessible and rates of smoking, obesity and diabetes are relatively high.  “The higher prevalence of dementia risk factors means an even greater proportion of dementia is potentially preventable than in higher-income countries,” says review co-author Adesola Ogunniyi at the University of Ibadan in Nigeria.

That means government interventions like increasing education and introducing anti-smoking campaigns could have an even bigger impact in lower and middle-income countries, says Ogunniyi. In Latin America, for example, it’s estimated that 56 per cent of dementia cases could be prevented or delayed by targeting the 12 risk factors.

However, there is a limit to how much you can prevent dementia with lifestyle interventions, because the brain inevitably starts to shut down in very old age, especially in people who live past 100, says Ames. “We’ve become very good at keeping people from dying of things like childhood diarrhea, and that means we now have a high life expectancy,” he says. “If you hang around long enough, something eventually has to catch you, and dementia is one of those diseases.”

Read more: https://www.newscientist.com/article/2250401-these-are-the-12-ways-you-can-drastically-cut-your-dementia-risk/#ixzz6ToII92qp