What Is Generative Design?

From: Autodesk

Generative design is a design exploration process. Designers or engineers input design goals into the generative design software, along with parameters such as performance or spatial requirements, materials, manufacturing methods, and cost constraints. The software explores all the possible permutations of a solution, quickly generating design alternatives. It tests and learns from each iteration what works and what doesn’t.

Quickly generate high-performing design alternatives—many that you’d never think of on your own—from a single idea. With generative design, there is no single solution; instead, there are multiple great solutions. You choose the design that best fits your needs.

https://www.autodesk.com/solutions/generative-design?mktvar002=678907&ef_id=Cj0KCQjw1PSDBhDbARIsAPeTqrdzpnED2iOdrVYKWBbQV_e2zoIDcjs7xK1LPOAcF3THcD_YUyYzIB4aAr-WEALw_wcB:G:s&s_kwcid=AL!11172!3!330171926122!e!!g!!generative%20design!621448685!27870611445&mkwid=sMxVoYQPt%7Cpcrid%7C330171926122%7Cpkw%7Cgenerative%20design%7Cpmt%7Ce%7Cpdv%7Cc%7Cslid%7C%7Cpgrid%7C27870611445%7Cptaid%7Ckwd-3935580345%7Cpid%7C&utm_medium=cpc&utm_source=google&utm_campaign=GGL_DM_FOMT-Generative_AMER_US_Visits_SEM_NBR_NEW_EX_ADSK_3461051&utm_term=generative%20design&utm_content=sMxVoYQPt%7Cpcrid%7C330171926122%7Cpkw%7Cgenerative%20design%7Cpmt%7Ce%7Cpdv%7Cc%7Cslid%7C%7Cpgrid%7C27870611445%7Cptaid%7Ckwd-3935580345%7C&gclid=Cj0KCQjw1PSDBhDbARIsAPeTqrdzpnED2iOdrVYKWBbQV_e2zoIDcjs7xK1LPOAcF3THcD_YUyYzIB4aAr-WEALw_wcB

The Ultimate Music Toy for Multi-Millionaires

Steinway has a new player piano available as a Spirio grand piano.  There is nothing like this.  Due to the complexity of the sounds coming out of a piano because of its dozens of strings and wooden drum, it is impossible to completely copy the sound electronically.

But the Steinway Spiro accomplishes this in a manner that is indistinguishable from live performance.  And the cost?  If you have to ask, you can’t get one.

Spirio Player Piano | Steinway & Sons - Steinway & Sons

Bright Future for Infinitely Recyclable Plastic

A new environmental and technological analysis suggests that a revolutionary eco-friendly plastic is almost ready to hit the shelves

From: Lawrence Berkeley National Laboratory

April 22, 2021 -- Plastics are a part of nearly every product we use on a daily basis. The average person in the U.S. generates about 100 kg of plastic waste per year, most of which goes straight to a landfill. A team led by Corinne Scown, Brett Helms, Jay Keasling, and Kristin Persson at Lawrence Berkeley National Laboratory (Berkeley Lab) set out to change that.

Less than two years ago, Helms announced the invention of a new plastic that could tackle the waste crisis head on. Called poly(diketoenamine), or PDK, the material has all the convenient properties of traditional plastics while avoiding the environmental pitfalls, because unlike traditional plastics, PDKs can be recycled indefinitely with no loss in quality.

Now, the team has released a study that shows what can be accomplished if manufacturers began using PDKs on a large scale. The bottom line? PDK-based plastic could quickly become commercially competitive with conventional plastics, and the products will get less expensive and more sustainable as time goes on.

“Plastics were never designed to be recycled. The need to do so was recognized long afterward,” explained Nemi Vora, first author on the report and a former postdoctoral fellow who worked with senior author Corinne Scown. “But driving sustainability is the heart of this project. PDKs were designed to be recycled from the get-go, and since the beginning, the team has been working to refine the production and recycling processes for PDK so that the material could be inexpensive and easy enough to be deployed at commercial scales in anything from packaging to cars.”

The study presents a simulation for a 20,000-metric-ton-per-year facility that puts out new PDKs and takes in used PDK waste for recycling. The authors calculated the chemical inputs and technology needed, as well as the costs and greenhouse gas emissions, then compared their findings to the equivalent figures for production of conventional plastics.

“These days, there is a huge push for adopting circular economy practices in the industry. Everyone is trying to recycle whatever they’re putting out in the market,” said Vora. “We started talking to industry about deploying 100% infinitely recycled plastics and have received a lot of interest.”

“The questions are how much it will cost, what the impact on energy use and emissions will be, and how to get there from where we are today,” added Helms, a staff scientist at Berkeley Lab’s Molecular Foundry. “The next phase of our collaboration is to answer these questions.”

Checking the boxes of cheap and easy

To date, more than 8.3 billion metric tons of plastic material have been produced, and the vast majority of this has ended up in landfills or waste incineration plants. A small proportion of plastics are sent to be recycled “mechanically,” meaning they are melted down and then re-shaped into new products. However, this technique has limited benefit. Plastic resin itself is made of many identical molecules (called monomers) bound together into long chains (called polymers). Yet to give plastic its many textures, colors, and capabilities, additives like pigments, heat stabilizers, and flame retardants are added to the resin. When many plastics are melted down together, the polymers become mixed with a slew of potentially incompatible additives, resulting in a new material with much lower quality than newly produced virgin resin from raw materials. As such, less than 10% of plastic is mechanically recycled more than once, and recycled plastic usually also contains virgin resin to make up for the dip in quality.

PDK plastics sidestep this problem entirely – the resin polymers are engineered to easily break down into individual monomers when mixed with an acid. The monomers can then be separated from any additives and gathered to make new plastics without any loss of quality. The team’s earlier research shows that this “chemical recycling” process is light on energy and carbon dioxide emissions, and it can be repeated indefinitely, creating a completely circular material lifecycle where there is currently a one-way ticket to waste.

Yet despite these incredible properties, to truly beat plastics at their own game, PDKs also need to be convenient. Recycling traditional petroleum-based plastic might be hard, but making new plastic is very easy.

“We’re talking about materials that are basically not recycled,” said Scown. “So, in terms of appealing to manufacturers, PDKs aren’t competing with recycled plastic – they have to compete with virgin resin. And we were really pleased to see how cheap and how efficient it will be to recycle the material.”

Scown, who is a staff scientist in Berkeley Lab’s Energy Technologies and Biosciences Areas, specializes in modeling future environmental and financial impacts of emerging technologies. Scown and her team have been working on the PDK project since the outset, helping Helms’ group of chemists and fabrication scientists to choose the raw materials, solvents, equipment, and techniques that will lead to the most affordable and eco-friendly product.

“We’re taking early stage technology and designing what it would look like at commercial-scale operations” using different inputs and technology, she said. This unique, collaborative modeling process allows Berkeley Lab scientists to identify potential scale-up challenges and make process improvements without costly cycles of trial and error.

The team’s report, published in Science Advances, models a commercial-scale PDK production and recycling pipeline based on the plastic’s current state of development. “And the main takeaways were that, once you’ve produced the PDK initially and you’ve got it in the system, the cost and the greenhouse gas emissions associated with continuing to recycle it back to monomers and make new products could be lower than, or at least on par with, many conventional polymers,” said Scown.

Planning to launch

Thanks to optimization from process modeling, recycled PDKs are already drawing interest from companies needing to source plastic. Always looking to the future, Helms and his colleagues have been conducting market research and meeting with people from industry since the project’s early days. Their legwork shows that the best initial application for PDKs are markets where the manufacturer will receive their product back at the end of its lifespan, such as the automobile industry (through trade-ins and take-backs) and consumer electronics (through e-waste programs). These companies will then be able to reap the benefits of 100% recyclable PDKs in their product: sustainable branding and long-term savings.

“With PDKs, now people in industry have a choice,” said Helms. “We’re bringing in partners who are building circularity into their product lines and manufacturing capabilities, and giving them an option that is in line with future best practices.”

Added Scown: “We know there’s interest at that level. Some countries have plans to charge hefty fees on plastic products that rely on non-recycled material. That shift will provide a strong financial incentive to move away from utilizing virgin resins and should drive a lot of demand for recycled plastics.”

After infiltrating the market for durable products like cars and electronics, the team hopes to expand PDKs into shorter-lived, single-use goods such as packaging.

A full-circle future

As they forge plans for a commercial launch, the scientists are also continuing their techno-economic collaboration on the PDK production process. Although the cost of recycled PDK is already projected to be competitively low, the scientists are working on additional refinements to lower the cost of virgin PDK, so that companies are not deterred by the initial investment price.

And true to form, the scientists are working two steps ahead at the same time. Scown, who is also vice president for Life-cycle, Economics & Agronomy at the Joint BioEnergy Institute (JBEI), and Helms are collaborating with Jay Keasling, a leading synthetic biologist at Berkeley Lab and UC Berkeley and CEO of JBEI, to design a process for producing PDK polymers using microbe-made precursor ingredients. The process currently uses industrial chemicals, but was initially designed with Keasling’s microbes in mind, thanks to a serendipitous cross-disciplinary seminar.

“Shortly before we started the PDK project, I was in a seminar where Jay was describing all the molecules that they could make at JBEI with their engineered microbes,” said Helms. “And I got very excited because I saw that some of those molecules were things that we put in PDKs. Jay and I had a few chats, and we realized that nearly the entire polymer could be made using plant material fermented by engineered microbes.”

“In the future, we’re going to bring in that biological component, meaning that we can begin to understand the impacts of transitioning from conventional feedstocks to unique and possibly advantaged bio-based feedstocks that might be more sustainable long term on the basis of energy, carbon, or water intensity of production and recycling,” Helms continued.

“So, where we are now, this is the first step of many, and I think we have a really long runway in front of us, which is exciting.”

The Molecular Foundry is a Department of Energy (DOE) Office of Science user facility that specializes in nanoscale science. JBEI is a Bioenergy Research Center funded by DOE’s Office of Science.

           The Future Looks Bright for Infinitely Recyclable Plastic (lbl.gov)

Undersea Volcanoes Release Enormous Heat

Energy unleashed by submarine volcanoes could power a continent

From:   Leeds University

April 21, 2021 -- Eruptions from deep-sea volcanoes were long-thought to be relatively uninteresting compared with those on land. While terrestrial volcanoes often produce spectacular eruptions, dispersing volcanic ash into the environment, it was thought  that deep marine eruptions only produced slow moving lava flows.

But data gathered by remotely operated vehicles deep in the North East Pacific and analysed by scientists at the University of Leeds, has revealed a link between the way ash is dispersed during submarine eruptions and the creation of large and powerful columns of heated water rising from the ocean floor, known as megaplumes.

These megaplumes contain hot chemical-rich water and act in the same way as the atmospheric plumes seen from land-based volcanoes, spreading first upwards and then outwards, carrying volcanic ash with them. The size of megaplumes is immense, with the volumes of water equivalent to forty million Olympic-sized swimming pools. They have been detected above various submarine volcanoes but their origin has remained unknown. The results of this new research show that they form rapidly during the eruption of lava. 

 The research was carried out by Dr Sam Pegler, from the School of Mathematics and Dr David Ferguson, from the School of Earth and Environment and is being published today in the journal Nature Communications. 

Together they developed a mathematical model which shows how ash from these submarine eruptions spreads several kilometres from the volcano. They used the ash pattern deposited by a historic submarine eruption to reconstruct its dynamics. This showed  that the rate of energy released and required to carry ash to the observed distances is extremely high – equivalent to the   power used by the whole of the USA. 

Dr Ferguson said: “The majority of Earth’s volcanic activity occurs underwater, mostly at depths of several kilometres in the deep ocean but, in contrast to terrestrial volcanoes, even detecting that an eruption has occurred on the seafloor is extremely challenging. Consequently, there remains much for scientists to learn about submarine volcanism and its effects on the marine environment.”

The research shows that submarine eruptions cause megaplumes to form but the release of energy is so rapid that it cannot be supplied from the erupted molten lava alone.  Instead, the research concludes that submarine volcanic eruptions lead to the rapid emptying of reservoirs of hot fluids within the earth’s crust. As the magma forces its way upwards towards the seafloor, it drives this hot fluid with it.

Dr Pegler said: “Our work provides evidence that megaplumes are directly linked to the eruption of lava and are responsible for transporting volcanic ash in the deep ocean. It also shows that plumes must have formed in a matter of hours, creating an immense rate of energy release.”

Dr Ferguson added: “Observing a submarine eruption in person remains extremely difficult but the development of instruments based on the seafloor means data can be streamed live as the activity occurs. 

“Efforts like these, in concert with continued mapping and sampling of the ocean floor means the volcanic character of our oceans is slowly being revealed.”   

Further information

Rapid heat discharge during deep-sea eruptions generates megaplumes and disperses tephra is published in Nature Communications 22 April 10:00 GMT. DOI:10.1038/s41467-021-22439-y.

http://www.leeds.ac.uk/news/article/4803/energy_unleashed_by_submarine_volcanoes_could_power_a_continent

Human-Monkey Chimeric Embryos Generated

Researchers have injected human stem cells into primate embryos and were able to grow chimeric embryos for a significant period of time -- up to 20 days. The research, despite its ethical concerns, has the potential to provide new insights into developmental biology and evolution. It also has implications for developing new models of human biology and disease.

From:  Cell Press

April 15, 2021 -- Investigators in China and the United States have injected human stem cells into primate embryos and were able to grow chimeric embryos for a significant period of time -- up to 20 days. The research, despite its ethical concerns, has the potential to provide new insights into developmental biology and evolution. It also has implications for developing new models of human biology and disease. The work appears April 15 in the journal Cell.

"As we are unable to conduct certain types of experiments in humans, it is essential that we have better models to more accurately study and understand human biology and disease," says senior author Juan Carlos Izpisua Belmonte, a professor in the Gene Expression Laboratory at the Salk Institute for Biological Sciences. "An important goal of experimental biology is the development of model systems that allow for the study of human diseases under in vivo conditions."

Interspecies chimeras in mammals have been made since the 1970s, when they were generated in rodents and used to study early developmental processes. The advance that made the current study possible came last year when this study's collaborating team -- led by Weizhi Ji of Kunming University of Science and Technology in Yunnan, China -- generated technology that allowed monkey embryos to stay alive and grow outside the body for an extended period of time.

In the current study, six days after the monkey embryos had been created, each one was injected with 25 human cells. The cells were from an induced pluripotent cell line known as extended pluripotent stem cells, which have the potential to contribute to both embryonic and extra-embryonic tissues. After one day, human cells were detected in 132 embryos. After 10 days, 103 of the chimeric embryos were still developing. Survival soon began declining, and by day 19, only three chimeras were still alive. Importantly, though, the percentage of human cells in the embryos remained high throughout the time they continued to grow.

"Historically, the generation of human-animal chimeras has suffered from low efficiency and integration of human cells into the host species," Izpisua Belmonte says. "Generation of a chimera between human and non-human primate, a species more closely related to humans along the evolutionary timeline than all previously used species, will allow us to gain better insight into whether there are evolutionarily imposed barriers to chimera generation and if there are any means by which we can overcome them."

The investigators performed transcriptome analysis on both the human and monkey cells from the embryos. "From these analyses, several communication pathways that were either novel or strengthened in the chimeric cells were identified," Izpisua Belmonte explains. "Understanding which pathways are involved in chimeric cell communication will allow us to possibly enhance this communication and increase the efficiency of chimerism in a host species that's more evolutionarily distant to humans."

An important next step for this research is to evaluate in more detail all the molecular pathways that are involved in this interspecies communication, with the immediate goal of finding which pathways are vital to the developmental process. Longer term, the researchers hope to use the chimeras not only to study early human development and to model disease, but to develop new approaches for drug screening, as well as potentially generating transplantable cells, tissues, or organs.

An accompanying Preview in Cell outlines potential ethical considerations surrounding the generation of human/non-human primate chimeras. Izpisua Belmonte also notes that "it is our responsibility as scientists to conduct our research thoughtfully, following all the ethical, legal, and social guidelines in place." He adds that before beginning this work, "ethical consultations and reviews were performed both at the institutional level and via outreach to non-affiliated bioethicists. This thorough and detailed process helped guide our experiments."

         Scientists generate human-monkey chimeric embryos -- ScienceDaily

Boosting AI With Light and Superconductors

As artificial intelligence has attracted interest, researchers are focused on understanding how the brain accomplishes cognition so they can construct systems with general intelligence comparable to humans' intelligence.

From:  American Institute of Physics

April 20, 2021 -- Researchers propose an approach to AI that focuses on integrating photonic components with superconducting electronics; using light for communication and complex electronic circuits for computation could enable artificial cognitive systems of scale and functionality beyond what can be achieved with either light or electronics alone.

Many have approached this challenge by using conventional silicon microelectronics in conjunction with light. However, the fabrication of silicon chips with electronic and photonic circuit elements is difficult for many physical and practical reasons related to the materials used for the components.

In Applied Physics Letters, by AIP Publishing, researchers at the National Institute of Standards and Technology propose an approach to large-scale artificial intelligence that focuses on integrating photonic components with superconducting electronics rather than semiconducting electronics.

"We argue that by operating at low temperature and using superconducting electronic circuits, single-photon detectors, and silicon light sources, we will open a path toward rich computational functionality and scalable fabrication," said author Jeffrey Shainline.

Using light for communication in conjunction with complex electronic circuits for computation could enable artificial cognitive systems of scale and functionality beyond what can be achieved with either light or electronics alone.

"What surprised me most was that optoelectronic integration may be much easier when working at low temperatures and using superconductors than when working at room temperatures and using semiconductors," said Shainline.

Superconducting photon detectors enable detection of a single photon, while semiconducting photon detectors require about 1,000 photons. So not only do silicon light sources work at 4 kelvins, but they also can be 1,000 times less bright than their room temperature counterparts and still communicate effectively.

Some applications, such as chips in cellphones, require working at room temperature, but the proposed technology would still have wide reaching applicability for advanced computing systems.

The researchers plan to explore more complex integration with other superconducting electronic circuits as well as demonstrate all the components that comprise artificial cognitive systems, including synapses and neurons.

Showing that the hardware can be manufactured in a scalable manner, so large systems can be realized at a reasonable cost, will also be important. Superconducting optoelectronic integration could also help create scalable quantum technologies based on superconducting or photonic qubits. Such quantum-neural hybrid systems may also lead to new ways of leveraging the strengths of quantum entanglement with spiking neurons.

https://www.sciencedaily.com/releases/2021/04/210420131057.htm

NASA Helicopter Flies on Mars

The small rotorcraft made history, hovering above Jezero Crater, demonstrating that powered, controlled flight on another planet is possible.

From: NASA Jet Propulsion Laboratory

April 19, 2021-- NASA's Ingenuity Mars Helicopter took this shot, capturing its own shadow, while hovering over the Martian surface on April 19, 2021, during the first instance of powered, controlled flight on another planet. It used its navigation camera, which autonomously tracks the ground during flight.

Monday, NASA's Ingenuity Mars Helicopter became the first aircraft in history to make a powered, controlled flight on another planet. The Ingenuity team at the agency's Jet Propulsion Laboratory in Southern California confirmed the flight succeeded after receiving data from the helicopter via NASA's Perseverance Mars rover at 6:46 a.m. EDT (3:46 a.m. PDT).

"Ingenuity is the latest in a long and storied tradition of NASA projects achieving a space exploration goal once thought impossible," said acting NASA Administrator Steve Jurczyk. "The X-15 was a pathfinder for the space shuttle. Mars Pathfinder and its Sojourner rover did the same for three generations of Mars rovers. We don't know exactly where Ingenuity will lead us, but today's results indicate the sky -- at least on Mars -- may not be the limit."

The solar-powered helicopter first became airborne at 3:34 a.m. EDT (12:34 a.m. PDT) -- 12:33 Local Mean Solar Time (Mars time) -- a time the Ingenuity team determined would have optimal energy and flight conditions. Altimeter data indicate Ingenuity climbed to its prescribed maximum altitude of 10 feet (3 meters) and maintained a stable hover for 30 seconds. It then descended, touching back down on the surface of Mars after logging a total of 39.1 seconds of flight. Additional details on the test are expected in upcoming downlinks.

Ingenuity's initial flight demonstration was autonomous -- piloted by onboard guidance, navigation, and control systems running algorithms developed by the team at JPL. Because data must be sent to and returned from the Red Planet over hundreds of millions of miles using orbiting satellites and NASA's Deep Space Network, Ingenuity cannot be flown with a joystick, and its flight was not observable from Earth in real time.

NASA Associate Administrator for Science Thomas Zurbuchen announced the name for the Martian airfield on which the flight took place.

"Now, 117 years after the Wright brothers succeeded in making the first flight on our planet, NASA's Ingenuity helicopter has succeeded in performing this amazing feat on another world," Zurbuchen said. "While these two iconic moments in aviation history may be separated by time and 173 million miles of space, they now will forever be linked. As an homage to the two innovative bicycle makers from Dayton, this first of many airfields on other worlds will now be known as Wright Brothers Field, in recognition of the ingenuity and innovation that continue to propel exploration."

Ingenuity's chief pilot, Håvard Grip, announced that the International Civil Aviation Organization (ICAO) -- the United Nations' civil aviation agency -- presented NASA and the Federal Aviation Administration with official ICAO designator IGY, call-sign INGENUITY.

These details will be included officially in the next edition of ICAO's publication Designators for Aircraft Operating Agencies, Aeronautical Authorities and Services. The location of the flight has also been given the ceremonial location designation JZRO for Jezero Crater.

As one of NASA's technology demonstration projects, the 19.3-inch-tall (49-centimeter-tall) Ingenuity Mars Helicopter contains no science instruments inside its tissue-box-size fuselage. Instead, the 4-pound (1.8-kg) rotorcraft is intended to demonstrate whether future exploration of the Red Planet could include an aerial perspective.

This first flight was full of unknowns. The Red Planet has a significantly lower gravity -- one-third that of Earth's -- and an extremely thin atmosphere with only 1% the pressure at the surface compared to our planet. This means there are relatively few air molecules with which Ingenuity's two 4-foot-wide (1.2-meter-wide) rotor blades can interact to achieve flight. The helicopter contains unique components, as well as off-the-shelf-commercial parts -- many from the smartphone industry -- that were tested in deep space for the first time with this mission.

"The Mars Helicopter project has gone from 'blue sky' feasibility study to workable engineering concept to achieving the first flight on another world in a little over six years," said Michael Watkins, director of JPL. "That this project has achieved such a historic first is testimony to the innovation and doggedness of our team here at JPL, as well as at NASA's Langley and Ames Research Centers, and our industry partners. It's a shining example of the kind of technology push that thrives at JPL and fits well with NASA's exploration goals."

Parked about 211 feet (64.3 meters) away at Van Zyl Overlook during Ingenuity's historic first flight, the Perseverance rover not only acted as a communications relay between the helicopter and Earth, but also chronicled the flight operations with its cameras. The pictures from the rover's Mastcam-Z and Navcam imagers will provide additional data on the helicopter's flight.

"We have been thinking for so long about having our Wright brothers moment on Mars, and here it is," said MiMi Aung, project manager of the Ingenuity Mars Helicopter at JPL. "We will take a moment to celebrate our success and then take a cue from Orville and Wilbur regarding what to do next. History shows they got back to work -- to learn as much as they could about their new aircraft -- and so will we."

Perseverance touched down with Ingenuity attached to its belly on Feb. 18. Deployed to the surface of Jezero Crater on April 3, Ingenuity is currently on the 16th sol, or Martian day, of its 30-sol (31-Earth day) flight test window. Over the next three sols, the helicopter team will receive and analyze all data and imagery from the test and formulate a plan for the second experimental test flight, scheduled for no earlier than April 22. If the helicopter survives the second flight test, the Ingenuity team will consider how best to expand the flight profile.

More About Ingenuity

JPL, which built Ingenuity, also manages the technology demonstration project for NASA. It is supported by NASA's Science, Aeronautics, and Space Technology mission directorates. The agency's Ames Research Center in California's Silicon Valley and Langley Research Center in Hampton, Virginia, provided significant flight performance analysis and technical assistance during Ingenuity's development.

Dave Lavery is the program executive for the Ingenuity Mars Helicopter, MiMi Aung is the project manager, and Bob Balaram is chief engineer.

NASA's Ingenuity Mars Helicopter succeeds in historic first flight -- ScienceDaily

NASA's Ingenuity Mars Helicopter succeeds in historic first flight -- ScienceDaily