Saturday, March 20, 2021

COVID-19 Worse and Deadlier than Flu

A new study compares the impact of COVID-19 on patients and hospital resources versus the impact of influenza.

From:  Beth Israel Deaconess Medical Center

March 19, 2021 -- In a paper published in the Journal of General Internal Medicine, physician-researchers at Beth Israel Deaconess Medical Center (BIDMC) assessed the relative impact of COVID-19 on patients hospitalized with the viral infection in March and April 2020, versus patients hospitalized with influenza during the last five flu seasons at the medical center. Overall, the team demonstrated that COVID-19 cases resulted in significantly more weekly hospitalizations, more use of mechanical ventilation and higher mortality rates than influenza.

COVID-19 and influenza are both contagious respiratory viral diseases that can lead to pneumonia and acute respiratory failure in severe cases. However, detailed comparison of the epidemiology and clinical characteristics of COVID-19 and those of influenza are lacking.

"COVID-19 has been compared to influenza both by health care professionals and the lay public, but there's really limited detailed objective data available for comparing and contrasting the impact of these two diseases on patients and hospitals," said corresponding author Michael Donnino, MD, Critical Care and Emergency Medicine physician at BIDMC. "We compared patients admitted to BIDMC with COVID-19 in spring 2020 to patients admitted to BIDMC with influenza during the last five flu seasons. We found that COVID-19 causes more severe disease and is more lethal than influenza."

Donnino and colleagues included a total of 1,634 hospitalized patients in their study, 582 of whom had laboratory-confirmed COVID-19 and 1,052 of whom had confirmed influenza. The team found that, on average, 210 patients were admitted to BIDMC during each eight-month flu season, compared to the 582 patients with COVID-19 admitted in March and April 2020. While 174 patients with COVID-19 (or 30 percent) received mechanical ventilation during the two-month period, just 84 patients with influenza (or 8 percent) were placed on ventilation over all five seasons of influenza. Likewise, the proportion of patients who died was much higher for COVID-19 than for influenza; 20 percent of admitted patients with COVID-19 died in the two-month period, compared to three percent of patients with influenza over five seasons.

Further analysis revealed that hospitalized patients with COVID-19 tended to be younger than those hospitalized with influenza. Among patients requiring mechanical ventilation, patients with COVID-19 were on ventilation much longer -- a median duration of two weeks -- compared to just over three days for patients with influenza. Moreover, among patients requiring mechanical ventilation, patients with COVID-19 were far less likely to have had pre-existing medical conditions.

"Our data illustrate that 98 percent of deaths of patients hospitalized with COVID-19 were directly or indirectly related to their COVID-19 illness, illustrating that patients did not die with COVID but rather from COVID pneumonia or a complication," said Donnino.

The authors note that the stringent social distancing guidance in effect last spring may have impacted these findings by limiting the incidence and lethality of COVID-19 toward the end of April 2020. Conversely, some treatment practices have evolved over the course of the pandemic, potentially improving outcomes for patients with COVID-19.

Co-authors included Ari Moskowitz, MD, Garrett S. Thompson, MPH, Stanley J. Heydrick, PhD, Rahul D. Pawar, MD, Katherine M. Berg, MD, Shivani Mehta, Parth V. Patel, BSN, RN, and Anne V. Grossestreuer, PhD, all of Beth Israel Deaconess Medical Center.

               https://www.sciencedaily.com/releases/2021/03/210319125433.htm

Friday, March 19, 2021

A Possible Cause of Poor Memory

Could a leak in the blood-brain barrier cause poor memory?

From: The University of Washington

March 18, 2021 – Have you forgotten where you laid your keys?  Ever wondered where you had parked your car? Or having trouble remembering the name of the new neighbor? Unfortunately, these things seem to get worse as one gets older. A big question for researchers is where does benign forgetfulness end and true disease begin?

One of the keys to having a healthy brain at any age is having a healthy blood-brain barrier, a complex interface of blood vessels that run through the brain. Researchers reviewed more than 150 articles to look at what happens to the blood-brain barrier as we age. Their findings were published March 15 in Nature Aging.

Whether the changes to the blood-brain barrier alters brain function is still up for debate. But research shows the blood-brain barrier leaks as we age, and we lose cells called pericytes. 

“It turns out very little is known how the blood-brain barrier ages,” said lead author William Banks, a gerontology researcher at the University of Washington School of Medicine and at the Veterans Affairs Puget Sound Health Care System. “It’s often hard to tell normal aging from early disease.”

The blood-brain barrier, discovered in the late 1800s, prevents the unregulated leakage of substances from blood into the brain. The brain is an especially sensitive organ and cannot tolerate direct exposure to many of the substances in the blood. Increasingly, scientists have realized that the blood-brain barrier also allows many substances into the brain in a regulated way to serve the nutritional needs of the brain. It also transports informational molecules from the blood to the brain and pumps toxins out of the brain. A malfunctioning blood-brain barrier can contribute to diseases such as multiple sclerosis, diabetes, and Alzheimer’s. 

Before scientists can understand how such malfunctioning can contribute to the diseases of aging, they need to understand how a healthy blood-brain barrier normally ages. 

Research shows that healthy aging individuals have a very small leak in their blood-brain barrier. This leakage is associated with some measures of the benign forgetfulness of aging, considered by most scientists to be normal. But could this leak and the difficulties in recall be the early stages of Alzheimer’s disease?

When a person carries the ApoE4 allele, the strongest genetic risk of Alzheimer’s risk, researchers said there is an acceleration of most of the blood-brain barrier age-related changes.

People with ApoE4 have a hard time getting rid of amyloid beta peptide in their brains, which causes an accumulation of plaque. With healthy aging, the pumps in the blood-brain barrier work less efficiently in getting rid of the amyloid beta peptide. The pumps work even less well in people with Alzheimer’s disease.

Another key finding in the review is that as we age, two cells begin to change in the blood-brain barrier: pericytes and astrocytes.

Recent work suggests that the leak in the blood-brain barrier that occurs with Alzheimer’s may be due to an age-related loss of pericytes. Astrocytes, by contrast, seem to be overactive. Recent work suggests that preserving pericyte function by giving the factors that they secrete or even transplanting them could lead to a healthier blood-brain barrier.

Some research suggests that pericyte health can be preserved by some of the same interventions that extend lifespan, such as regular exercise, caloric restriction, and rapamycin.

Other findings raise the question of whether the brain’s source of nutrition and its grip on control of the immune and endocrine systems could deteriorate with aging. Another finding raises the possibility that the rate at which many drugs are taken up by the brain may explain why older folks sometimes have different sensitivities to drugs than their children or grandchildren.

    https://newsroom.uw.edu/news/could-leak-blood-brain-barrier-be-cause-poor-memory

 

Thursday, March 18, 2021

What Is an Algorithm?

In mathematics and computer science, an algorithm is a finite sequence of well-defined, computer-implementable instructions, typically to solve a class of problems or to perform a computation.  Algorithms are always unambiguous and are used as specifications for performing calculations, data processing, automated reasoning, and other tasks.

As an effective method, an algorithm can be expressed within a finite amount of space and time, and in a well-defined formal language for calculating a function.  Starting from an initial state and initial input (perhaps empty), the instructions describe a computation that, when executed, proceeds through a finite number of well-defined successive states, eventually producing "output" and terminating at a final ending state. The transition from one state to the next is not necessarily deterministic; some algorithms, known as randomized algorithms, incorporate random input.

The concept of algorithm has existed since antiquity.  Arithmetic algorithms, such as a division algorithm, was used by ancient Babylonian mathematicians c. 2500 BC and Egyptian mathematicians c. 1550 BC.  Greek mathematicians later used algorithms in 240 BC in the sieve of Eratosthenes for finding prime numbers, and the Euclidean algorithm for finding the greatest common divisor of two numbers.  Arabic mathematicians such as al-Kindi in the 9th century  used cryptographic algorithms for code-breaking, based on frequency analysis.

The word algorithm itself is derived from the name of the 9th-century mathematician Muḥammad ibn Mūsā al-Khwārizmī, whose nisba (identifying him as from Khwarazm) was Latinized as Algoritmi.  A partial formalization of what would become the modern concept of algorithm began with attempts to solve the Entscheidungsproblem (decision problem) posed by David Hilbert in 1928.  Later formalizations were framed as attempts to define "effective calculability" or "effective method".  Those formalizations included the Gödel–Herbrand–Kleene recursive functions of 1930, 1934 and 1935, Alonzo Church's lambda calculus of 1936, Emil Post's Formulation 1 of 1936, and Alan Turing's Turing machines of 1936–37 and 1939.

Informal Definition

An informal definition could be "a set of rules that precisely defines a sequence of operations", which would include all computer programs (including programs that do not perform numeric calculations), and (for example) any prescribed bureaucratic procedure or cook-book recipe.

In general, a program is only an algorithm if it stops eventually  even though infinite loops may sometimes prove desirable.

A prototypical example of an algorithm is the Euclidean algorithm, which is used to determine the maximum common divisor of two integers; an example (there are others) is described by the flowchart above and as an example in a later section.

Boolos, Jeffrey & 1974, 1999 offer an informal meaning of the word "algorithm" in the following quotation:

No human being can write fast enough, or long enough, or small enough† ( †"smaller and smaller without limit … you'd be trying to write on molecules, on atoms, on electrons") to list all members of an enumerably infinite set by writing out their names, one after another, in some notation. But humans can do something equally useful, in the case of certain enumerably infinite sets: They can give explicit instructions for determining the nth member of the set, for arbitrary finite n. Such instructions are to be given quite explicitly, in a form in which they could be followed by a computing machine, or by a human who is capable of carrying out only very elementary operations on symbols.

An "enumerably infinite set" is one whose elements can be put into one-to-one correspondence with the integers. Thus Boolos and Jeffrey are saying that an algorithm implies instructions for a process that "creates" output integers from an arbitrary" input" integer or integers that, in theory, can be arbitrarily large. For example, an algorithm can be an algebraic equation such as y = m + n (i.e., two arbitrary "input variables" m and n that produce an output y), but various authors' attempts to define the notion indicate that the word implies much more than this, something on the order of (for the addition example):

Precise instructions (in a language understood by "the computer") for a fast, efficient, "good" process that specifies the "moves" of "the computer" (machine or human, equipped with the necessary internally contained information and capabilities) to find, decode, and then process arbitrary input integers/symbols m and n, symbols + and = … and "effectively" produce, in a "reasonable" time, output-integer y at a specified place and in a specified format.

The concept of algorithm is also used to define the notion of decidability—a notion that is central for explaining how formal systems come into being starting from a small set of axioms and rules.  In logic, the time that an algorithm requires to complete cannot be measured, as it is not apparently related to the customary physical dimension. From such uncertainties, that characterize ongoing work, stems the unavailability of a definition of algorithm that suits both concrete (in some sense) and abstract usage of the term.

Algorithm Design

Algorithm design refers to a method or a mathematical process for problem-solving and engineering algorithms. The design of algorithms is part of many solution theories of operation research, such as dynamic programming and divide-and-conquer.  Techniques for designing and implementing algorithm designs are also called algorithm design patterns, with examples including the template method pattern and the decorator pattern.

One of the most important aspects of algorithm design is resource (run-time, memory usage) efficiency; the big O notation is used to describe e.g. an algorithm's run-time growth as the size its input increases.

Typical steps in the development of algorithms:

  1. Problem definition
  2. Development of a model
  3. Specification of the algorithm
  4. Designing an algorithm
  5. Checking the correctness of the algorithm
  6. Analysis of algorithm
  7. Implementation of algorithm
  8. Program testing
  9. Documentation preparation

Computer Algorithms

In computer systems, an algorithm is basically an instance of logic written in software by software developers, to be effective for the intended "target" computer(s) to produce output from given (perhaps null) input. An optimal algorithm, even running in old hardware, would produce faster results than a non-optimal (higher time complexity) algorithm for the same purpose, running in more efficient hardware; that is why algorithms, like computer hardware, are considered technology.

"Elegant" (compact) programs, "good" (fast) programs: The notion of "simplicity and elegance" appears informally in Knuth and precisely in Chaitin:

Knuth: " … we want good algorithms in some loosely defined aesthetic sense. One criterion … is the length of time taken to perform the algorithm …. Other criteria are adaptability of the algorithm to computers, its simplicity and elegance, etc"

Chaitin: " … a program is 'elegant,' by which I mean that it's the smallest possible program for producing the output that it does"

Chaitin prefaces his definition with: "I'll show you can't prove that a program is 'elegant'"—such a proof would solve the Halting problem (ibid).

Algorithm versus function computable by an algorithm: For a given function multiple algorithms may exist. This is true, even without expanding the available instruction set available to the programmer. Rogers observes that "It is ... important to distinguish between the notion of algorithm, i.e. procedure and the notion of function computable by algorithm, i.e. mapping yielded by procedure. The same function may have several different algorithms".

Unfortunately, there may be a tradeoff between goodness (speed) and elegance (compactness)—an elegant program may take more steps to complete a computation than one less elegant. An example that uses Euclid's algorithm appears below.

Computers (and computors), models of computation: A computer (or human "computor") is a restricted type of machine, a "discrete deterministic mechanical device" that blindly follows its instructions.  Melzak's and Lambek's primitive models reduced this notion to four elements: (i) discrete, distinguishable locations, (ii) discrete, indistinguishable counters (iii) an agent, and (iv) a list of instructions that are effective relative to the capability of the agent.

Minsky describes a more congenial variation of Lambek's "abacus" model in his "Very Simple Bases for Computability".  Minsky's machine proceeds sequentially through its five (or six, depending on how one counts) instructions, unless either a conditional IF–THEN GOTO or an unconditional GOTO changes program flow out of sequence. Besides HALT, Minsky's machine includes three assignment (replacement, substitution) operations: ZERO (e.g. the contents of location replaced by 0: L ← 0), SUCCESSOR (e.g. L ← L+1), and DECREMENT (e.g. L ← L − 1).  Rarely must a programmer write "code" with such a limited instruction set. But Minsky shows (as do Melzak and Lambek) that his machine is Turing complete with only four general types of instructions: conditional GOTO, unconditional GOTO, assignment/replacement/substitution, and HALT. However, a few different assignment instructions (e.g. DECREMENT, INCREMENT, and ZERO/CLEAR/EMPTY for a Minsky machine) are also required for Turing-completeness; their exact specification is somewhat up to the designer. The unconditional GOTO is a convenience; it can be constructed by initializing a dedicated location to zero e.g. the instruction " Z ← 0 "; thereafter the instruction IF Z=0 THEN GOTO xxx is unconditional.

Simulation of an algorithm: computer (computor) language: Knuth advises the reader that "the best way to learn an algorithm is to try it . . . immediately take pen and paper and work through an example".  But what about a simulation or execution of the real thing? The programmer must translate the algorithm into a language that the simulator/computer/computor can effectively execute. Stone gives an example of this: when computing the roots of a quadratic equation the computor must know how to take a square root. If they don't, then the algorithm, to be effective, must provide a set of rules for extracting a square root.

This means that the programmer must know a "language" that is effective relative to the target computing agent (computer/computor).

But what model should be used for the simulation? Van Emde Boas observes "even if we base complexity theory on abstract instead of concrete machines, arbitrariness of the choice of a model remains. It is at this point that the notion of simulation enters".  When speed is being measured, the instruction set matters. For example, the subprogram in Euclid's algorithm to compute the remainder would execute much faster if the programmer had a "modulus" instruction available rather than just subtraction (or worse: just Minsky's "decrement").

Structured programming, canonical structures: Per the Church–Turing thesis, any algorithm can be computed by a model known to be Turing complete, and per Minsky's demonstrations, Turing completeness requires only four instruction types—conditional GOTO, unconditional GOTO, assignment, HALT. Kemeny and Kurtz observe that, while "undisciplined" use of unconditional GOTOs and conditional IF-THEN GOTOs can result in "spaghetti code", a programmer can write structured programs using only these instructions; on the other hand "it is also possible, and not too hard, to write badly structured programs in a structured language".  Tausworthe augments the three Böhm-Jacopini canonical structures: SEQUENCE, IF-THEN-ELSE, and WHILE-DO, with two more: DO-WHILE and CASE.  An additional benefit of a structured program is that it lends itself to proofs of correctness using mathematical induction.

Canonical flowchart symbols: The graphical aide called a flowchart, offers a way to describe and document an algorithm (and a computer program of one). Like the program flow of a Minsky machine, a flowchart always starts at the top of a page and proceeds down. Its primary symbols are only four: the directed arrow showing program flow, the rectangle (SEQUENCE, GOTO), the diamond (IF-THEN-ELSE), and the dot (OR-tie). The Böhm–Jacopini canonical structures are made of these primitive shapes. Sub-structures can "nest" in rectangles, but only if a single exit occurs from the superstructure. The symbols, and their use to build the canonical structures are shown in the diagram.

                              https://en.wikipedia.org/wiki/Algorithm

Wednesday, March 17, 2021

Cobalt and Titanium Catalysts Together

Clean Wastewater and Generate Hydrogen

From: The American Chemical Society

March 17, 2021 -- Hydrogen is a pollution-free energy source when it's extracted from water using sunlight instead of fossil fuels. But current strategies for "splitting" or breaking apart water molecules with catalysts and light require the introduction of chemical additives to expedite the process. Now, researchers reporting in ACS ES&T Engineering have developed a catalyst that destroys medications and other compounds already present in wastewater to generate hydrogen fuel, getting rid of a contaminant while producing something useful.

Harnessing the sun's energy to split water to make hydrogen fuel is a promising renewable resource, but it is a slow process even when catalysts are used to speed it along. In some cases, alcohols or sugars are added to boost the rate of hydrogen production, but these chemicals are destroyed as hydrogen is generated, meaning the approach is not renewable. In a separate strategy, researchers have tried using contaminants in wastewater to enhance hydrogen fuel generation. While titanium-based catalysts worked for both removing contaminants and generating hydrogen, the efficiencies were lower than expected for both steps because of their overlapping reaction sites. One way to reduce such interferences is to make catalysts by fusing together different conductive metals, thus creating separate places for reactions to occur. So, Chuanhao Li and colleagues wanted to combine cobalt oxide and titanium dioxide to create a dual-functioning catalyst that would break down common drugs in wastewater while also efficiently converting water into hydrogen for fuel.

To make the catalyst, the researchers coated nanoscale titanium dioxide crystals with a thin layer of cobalt oxide. Initial tests showed that this material didn't produce much hydrogen, so as a next step, the team spiked this dual catalyst with 1% by weight of platinum nanoparticles -- an efficient though expensive catalyst for generating hydrogen. In the presence of simulated sunlight, the platinum-impregnated catalyst degraded two antibiotics and produced substantial amounts of hydrogen. Finally, the team tested their product on real wastewater, water from a river in China and deionized water samples. Under simulated sunlight, the catalyst stimulated hydrogen production in all three samples. The greatest amount of hydrogen was obtained from the wastewater sample. The researchers say their catalyst could be a sustainable wastewater treatment option by generating hydrogen fuel at the same time.

           https://www.sciencedaily.com/releases/2021/03/210317141722.htm

Tuesday, March 16, 2021

Greenland Ice Has Melted Off Before!

University of Vermont scientists are stunned to discover plants beneath mile-deep Greenland ice.  Long-lost ice core from 1966 provides direct evidence that a deep, giant ice sheet melted off within the last million years and is highly vulnerable to a warming climate

From:  University of Vermont

March 15, 2021 -- In 1966, US Army scientists drilled down through nearly a mile of ice in northwestern Greenland—and pulled up a fifteen-foot-long tube of dirt from the bottom. Then this frozen sediment was lost in a freezer for decades. It was accidentally rediscovered in 2017.

In 2019, University of Vermont scientist Andrew Christ looked at it through his microscope—and couldn’t believe what he was seeing: twigs and leaves instead of just sand and rock. That suggested that the ice was gone in the recent geologic past—and that a vegetated landscape, perhaps a boreal forest, stood where a mile-deep ice sheet as big as Alaska stands today.

Over the last year, Christ and an international team of scientists—led by Paul Bierman at UVM, Joerg Schaefer at Columbia University and Dorthe Dahl-Jensen at the University of Copenhagen—have studied these one-of-a-kind fossil plants and sediment from the bottom of Greenland. Their results show that most, or all, of Greenland must have been ice-free within the last million years, perhaps even the last few hundred-thousand years.

“Ice sheets typically pulverize and destroy everything in their path,” says Christ, “but what we discovered was delicate plant structures—perfectly preserved. They’re fossils, but they look like they died yesterday. It’s a time capsule of what used to live on Greenland that we wouldn’t be able to find anywhere else.”

The discovery helps confirm a new and troubling understanding that the Greenland ice has melted off entirely during recent warm periods in Earth’s history—periods like the one we are now creating with human-caused climate change.

Understanding the Greenland Ice Sheet in the past is critical for predicting how it will respond to climate warming in the future and how quickly it will melt. Since some twenty feet of sea-level rise is tied up in Greenland’s ice, every coastal city in the world is at risk. The new study provides the strongest evidence yet that Greenland is more fragile and sensitive to climate change than previously understood—and at grave risk of irreversibly melting off.

“This is not a twenty-generation problem,” says Paul Bierman, a geoscientist at UVM in the College of Arts & Sciences, Rubenstein School of Environment & Natural Resources, and fellow in the Gund Institute for Environment. “This is an urgent problem for the next 50 years.”

The new research was published March 15 in the Proceedings of the National Academy of Sciences.

BENEATH THE ICE
The material for the new PNAS study came from Camp Century, a Cold War military base dug inside the ice sheet far above the Arctic Circle in the 1960s. The real purpose of the camp was a super-secret effort, called Project Iceworm, to hide 600 nuclear missiles under the ice close to the Soviet Union. As cover, the Army presented the camp as a polar science station.

The military mission failed, but the science team did complete important research, including drilling a 4560-foot-deep ice core. The Camp Century scientists were focused on the ice itself—part of the burgeoning effort at the time to understand the deep history of Earth’s ice ages. They, apparently, took less interest in a bit of dirt gathered from beneath the ice core. Then, in a truly cinematic set of strange plot twists, the ice core was moved from an Army freezer to the University of Buffalo in the 1970s, to another freezer in Copenhagen, Denmark, in the 1990s, where it languished for decades—until it surfaced when the cores were being moved to a new freezer.

More about how the core was lost, rediscovered in some cookie jars, and then studied by an international team gathered at the University of Vermont in 2019 can be read here: Secrets Under the Ice.

For much of the Pleistocene—the icy period covering the last 2.6 million years—portions of the ice on Greenland persisted even during warmer spells called “interglacials.” But most of this general story has been pieced together from indirect evidence in mud and rock that washed off the island and was gathered by offshore ocean drilling. The extent of Greenland’s ice sheet and what kinds of ecosystems existed there before the last interglacial warm period—that ended about 120,000 years ago—have been hotly debated and poorly understood.

The new study makes clear that the deep ice at Camp Century—some 75 miles inland from the coast and only 800 miles from the North Pole—entirely melted at least once within the last million years and was covered with vegetation, including moss and perhaps trees. The new research, supported by the National Science Foundation, lines up with data from two other ice cores from the center of Greenland, collected in 1990s. Sediment from the bottom of these cores also indicate that the ice sheet was gone for some time in the recent geologic past. The combination of these cores from the center of Greenland with the new insight from Camp Century in the far northwest give researchers an unprecedented view of the shifting fate of the entire Greenland ice sheet.

The team of scientists used a series of advanced analytical techniques—none of which were available to researchers fifty years ago—to probe the sediment, fossils, and the waxy coating of leaves found at the bottom of the Camp Century ice core.  For example, they measured ratios of rare forms—isotopes—of both aluminum and the element beryllium that form in quartz only when the ground is exposed to the sky and can be hit by cosmic rays. These ratios gave the scientists a window onto how long rocks at the surface were exposed vs. buried under layers of ice. This analysis gives the scientists a kind of clock for measuring what was happening on Greenland in the past. Another test used rare forms of oxygen, found in the ice within the sediment, to reveal that precipitation must have fallen at much lower elevations than the height of the current ice sheet, “demonstrating ice sheet absence,” the team writes. Combining these techniques with studies of luminescence that estimate the amount of time since sediment was exposed to light, radiocarbon-dating of bits of wood in the ice, and analysis of how layers of ice and debris were arranged—allowed the team to be clear that most, if not all, of Greenland melted at least once during the past million years—making Greenland green with moss and lichen, and perhaps with spruce and fir trees.

And the new study shows that ecosystems of the past were not scoured into oblivion by ages of glaciers and ice sheets bulldozing overtop. Instead, the story of these living landscapes remains captured under the relatively young ice that formed on top of the ground, frozen in place, and holds them still.

In a 1960’s movie about Camp Century created by the Army, the narrator notes that “more than ninety percent of Greenland is permanently frozen under a polar ice cap.” This new study makes clear that it’s not as permanent as we once thought. “Our study shows that Greenland is much more sensitive to natural climate warming than we used to think—and we already know that humanity’s out-of-control warming of the planet hugely exceeds the natural rate,” says Christ, a postdoctoral researcher in the College of Arts & Sciences and Gund Institute.

“Greenland may seem far away,” says UVM’s Paul Bierman, “but it can quickly melt, pouring enough into the oceans that New York, Miami, Dhaka—pick your city—will go underwater.”

https://www.uvm.edu/uvmnews/news/uvm-scientists-stunned-discover-plants-beneath-mile-deep-greenland-ice

Monday, March 15, 2021

Your Brain If You 'Lose Yourself' in Fiction

Study examines fans of 'Game of Thrones' characters

From:  Ohio State University

March 15, 2021 -- If you count yourself among those who lose themselves in the lives of fictional characters, scientists now have a better idea of how that happens. Researchers found that the more immersed people tend to get into 'becoming' a fictional character, the more they use the same part of the brain to think about the character as they do to think about themselves.

"When they think about a favorite fictional character, it appears similar in one part of the brain as when they are thinking about themselves," said Timothy Broom, lead author of the study and doctoral student in psychology at The Ohio State University.

The study was published online recently in the journal Social Cognitive and Affective Neuroscience.

The study involved scanning the brains of 19 self-described fans of the HBO series "Game of Thrones" while they thought about themselves, nine of their friends and nine characters from the series. (The characters were Bronn, Catelyn Stark, Cersei Lannister, Davos Seaworth, Jaime Lannister, Jon Snow, Petyr Baelish, Sandor Clegane and Ygritte.)

Participants reported which "Game of Thrones" character they felt closest to and liked the most.

"Game of Thrones" was a fantasy drama series lasting eight seasons and concerning political and military conflicts between ruling families on two fictional continents. It was ideal for this study, Broom said, because it attracted a devoted fan base and the large cast presented a variety of characters that people could become attached to.

One of the key findings involved participants in the study who scored highest on what is called "trait identification." In a questionnaire they completed as part of the study, these participants agreed most strongly with statements like "I really get involved in the feelings of the characters in a novel."

"People who are high in trait identification not only get absorbed into a story, they also are really absorbed into a particular character," Broom said. "They report matching the thoughts of the character, they are thinking what the character is thinking, they are feeling what the character is feeling. They are inhabiting the role of that character."

For the study, the participants' brains were scanned in an fMRI machine while they evaluated themselves, friends and "Game of Thrones" characters. An fMRI indirectly measures activity in various parts of the brain through small changes in blood flow.

The researchers were particularly interested in what was happening in a part of the brain called the ventral medial prefrontal cortex (vMPFC), which shows increased activity when people think about themselves and, to a lesser extent, when thinking about close friends.

The process was simple. While in the fMRI, participants were shown a series of names -- sometimes themselves, sometimes one of their nine friends, and other times one of the nine characters from "Game of Thrones." Each name appeared above a trait, like lonely, sad, trustworthy or smart.

Participants simply said "yes" or "no" to whether the trait described the person while the researchers simultaneously measured activity in the vMPFC portion of their brains.

As expected, the vMPFC was most active when people were evaluating themselves, less active when they evaluated friends, and least active when they evaluated "Game of Thrones" characters.

But for those who were high in trait identification, the vMPFC was more active when they thought about the fictional characters than it was for participants who identified less with the characters. That brain area was especially active when they evaluated the character they felt closest to and liked the most.

The findings help explain how fiction can have such a big impact on some people, said Dylan Wanger, co-author of the study and assistant professor of psychology at Ohio State.

"For some people, fiction is a chance to take on new identities, to see worlds though others' eyes and return from those experiences changed," Wagner said.

"What previous studies have found is that when people experience stories as if they were one of the characters, a connection is made with that character, and the character becomes intwined with the self. In our study, we see evidence of that in their brains."

           https://www.sciencedaily.com/releases/2021/03/210315132143.htm

Sunday, March 14, 2021

Humans Similar to Earth’s Earliest Animals

Today's humans share genes with ancient oceanic creatures missing heads

From: University of California Riverside

March 8, 2021 -- The earliest multicellular organisms may have lacked heads, legs, or arms, but pieces of them remain inside of us today, new research shows. According to a new study, 555-million-year-old oceanic creatures from the Ediacaran period share genes with today's animals, including humans.

The earliest multicellular organisms may have lacked heads, legs, or arms, but pieces of them remain inside of us today, new research shows.

According to a UC Riverside study, 555-million-year-old oceanic creatures from the Ediacaran period share genes with today's animals, including humans.

"None of them had heads or skeletons. Many of them probably looked like three-dimensional bathmats on the sea floor, round discs that stuck up," said Mary Droser, a geology professor at UCR. "These animals are so weird and so different, it's difficult to assign them to modern categories of living organisms just by looking at them, and it's not like we can extract their DNA -- we can't."

However, well-preserved fossil records have allowed Droser and the study's first author, recent UCR doctoral graduate Scott Evans, to link the animals' appearance and likely behaviors to genetic analysis of currently living things. Their research on these links has been recently published in the journal Proceedings of the Royal Society B.

For their analysis, the researchers considered four animals representative of the more than 40 recognized species that have been identified from the Ediacaran era. These creatures ranged in size from a few millimeters to nearly a meter in length.

Kimberella were teardrop-shaped creatures with one broad, rounded end and one narrow end that likely scraped the sea floor for food with a proboscis. Further, they could move around using a "muscular foot" like snails today. The study included flat, oval-shaped Dickinsonia with a series of raised bands on their surface, and Tribrachidium, who spent their lives immobilized at the bottom of the sea.

Also analyzed were Ikaria, animals recently discovered by a team including Evans and Droser. They were about the size and shape of a grain of rice, and represent the first bilaterians -- organisms with a front, back, and openings at either end connected by a gut. Evans said it's likely Ikaria had mouths, though those weren't preserved in the fossil records, and they crawled through organic matter "eating as they went."

All four of the animals were multicellular, with cells of different types. Most had symmetry on their left and right sides, as well as noncentralized nervous systems and musculature.

Additionally, they seem to have been able to repair damaged body parts through a process known as apoptosis. The same genes involved are key elements of human immune systems, which helps to eliminate virus-infected and pre-cancerous cells.

These animals likely had the genetic parts responsible for heads and the sensory organs usually found there. However, the complexity of interaction between these genes that would give rise to such features hadn't yet been achieved.

"The fact that we can say these genes were operating in something that's been extinct for half a billion years is fascinating to me," Evans said.

The work was supported by a NASA Exobiology grant, and a Peter Buck postdoctoral fellowship.

Going forward, the team is planning to investigate muscle development and functional studies to further understand early animal evolution.

"Our work is a way to put these animals on the tree of life, in some respects," Droser said. "And show they're genetically linked to modern animals, and to us."

               https://www.sciencedaily.com/releases/2021/03/210308111844.htm