Saturday, October 31, 2020

Sean Connery Dies at 90

Sir Thomas Sean Connery (25 August 1930 – 31 October 2020) was a Scottish actor and producer. He is best known as the first actor to portray the character James Bond in film, starring in seven Bond films (every film from Dr. No to You Only Live Twice, plus Diamonds Are Forever and Never Say Never Again) between 1962 and 1983.

Connery was in smaller theatre and television productions until he got his break with the Bond films. He became a major actor with the success of his Bond role. His films also included Marnie (1964), Murder on the Orient Express (1974), The Man Who Would Be King (1975), A Bridge Too Far (1977), Highlander (1986), The Name of the Rose (1986), The Untouchables (1988), Indiana Jones and the Last Crusade (1989), The Hunt for Red October (1990), Dragonheart (1996), The Rock (1996), and Finding Forrester (2000). Connery retired from acting in 2006. His achievements include one Academy Award, two BAFTA Awards (one being a BAFTA Academy Fellowship Award), and three Golden Globes, including the Cecil B. DeMille Award and a Henrietta Award. He received a lifetime achievement award in the US with a Kennedy Center Honor in 1999. Connery was knighted in the 2000 New Year Honours for services to film drama.

Connery was polled in a 2004 The Sunday Herald as "The Greatest Living Scot" and in a 2011 EuroMillions survey as "Scotland's Greatest Living National Treasure". He was voted by People magazine as both the "Sexiest Man Alive" in 1989 and the "Sexiest Man of the Century" in 1999.

James Bond: 1962–1971, 1983

Connery's breakthrough came in the role of British secret agent James Bond. He was reluctant to commit to a film series, but understood that if the films succeeded, his career would greatly benefit. He played 007 in the first five Bond films: Dr. No (1962), From Russia with Love (1963), Goldfinger (1964), Thunderball (1965), and You Only Live Twice (1967) – then appeared again as Bond in Diamonds Are Forever (1971) and Never Say Never Again (1983). All seven films were commercially successful. James Bond, as portrayed by Connery, was selected as the third-greatest hero in cinema history by the American Film Institute.

Connery's selection for the role of James Bond owed a lot to Dana Broccoli, wife of producer Albert "Cubby" Broccoli, who is reputed to have been instrumental in persuading her husband that Connery was the right man. James Bond's creator, Ian Fleming, originally doubted Connery's casting, saying, "He's not what I envisioned of James Bond looks", and "I'm looking for Commander Bond and not an overgrown stunt-man", adding that Connery (muscular, 6' 2", and a Scot) was unrefined. Fleming's girlfriend Blanche Blackwell told him that Connery had the requisite sexual charisma, and Fleming changed his mind after the successful Dr. No première. He was so impressed, he wrote Connery's heritage into the character. In his 1964 novel You Only Live Twice, Fleming wrote that Bond's father was Scottish and from Glencoe in the Scottish Highlands.

Connery's portrayal of Bond owes much to stylistic tutelage from director Terence Young, which helped polish him while using his physical grace and presence for the action. Lois Maxwell, who played Miss Moneypenny, related that "Terence took Sean under his wing. He took him to dinner, showed him how to walk, how to talk, even how to eat." The tutoring was successful; Connery received thousands of fan letters a week after Dr. No’s opening, and he became a major sex symbol in film.

During the filming of Thunderball in 1965, Connery's life was in danger in the sequence with the sharks in Emilio Largo's pool. He had been concerned about this threat when he read the script. Connery insisted that Ken Adam build a special Plexiglas partition inside the pool, but this was not a fixed structure, and one of the sharks managed to pass through it. He had to abandon the pool immediately.

Career Beyond Bond

Although Bond had made him a star, Connery grew tired of the role and the pressure the franchise put on him, saying "[I am] fed up to here with the whole Bond bit" and "I have always hated that damned James Bond. I'd like to kill him". Michael Caine said of the situation, "If you were his friend in these early days you didn't raise the subject of Bond. He was, and is, a much better actor than just playing James Bond, but he became synonymous with Bond. He'd be walking down the street and people would say, "Look, there's James Bond." That was particularly upsetting to him."

While making the Bond films, Connery also starred in other films such as Alfred Hitchcock's Marnie (1964) and Sidney Lumet's The Hill (1965). In Marnie, Connery starred opposite Tippi Hedren. Connery had stated that he wanted to work with Hitchcock, which Eon arranged through their contacts. Connery also shocked many people at the time by asking to see a script; something Connery did because he was worried about being typecast as a spy and he did not want to do a variation of North by Northwest or Notorious. When told by Hitchcock's agent that Cary Grant did not ask to see even one of Hitchcock's scripts Connery replied, "I'm not Cary Grant." Hitchcock and Connery got on well during filming. Connery also said that he was happy with the film "with certain reservations." In The Hill, Connery wanted to act in something that wasn't Bond related, and used his leverage as a star to star in the film. While the film wasn't a financial success it was a critical one, debuting at the Cannes Film Festival winning Best Screenplay.

Having played Bond six times, Connery's global popularity was such that he shared a Golden Globe Henrietta Award with Charles Bronson for "World Film Favorite – Male" in 1972. He appeared in John Huston’s The Man Who Would Be King (1975) opposite Michael Caine, with both actors regarding it as their favourite film. The same year, he appeared in The Wind and the Lion, and in 1976 played Robin Hood in Robin and Marian where he starred opposite Audrey Hepburn who played Maid Marian. Film critic Roger Ebert, who had praised the double act of Connery and Caine in The Man Who Would Be King, praised Connery’s chemistry with Hepburn, writing: "Connery and Hepburn seem to have arrived at a tacit understanding between themselves about their characters. They glow. They really do seem in love."

In the 1970s Connery was part of ensemble casts in films such as Murder on the Orient Express (1974) with Vanessa Redgrave and John Gielgud, and A Bridge Too Far (1977) co-starring Dirk Bogarde and Laurence Olivier. In 1981, Connery appeared in the film Time Bandits as Agamemnon. The casting choice derives from a joke Michael Palin included in the script, in which he describes the character removing his mask as being "Sean Connery– or someone of equal but cheaper stature". When shown the script, Connery was happy to play the supporting role. In 1982, Connery narrated G'olé!, the official film of the 1982 FIFA World Cup.

Connery agreed to reprise Bond as an ageing agent 007 in Never Say Never Again, released in October 1983. The title, contributed by his wife, refers to his earlier statement that he would "never again" return to the role. Although the film performed well at the box office, it was plagued with production problems: strife between the director and producer, financial problems, the Fleming estate trustees' attempts to halt the film, and Connery's wrist being broken by fight choreographer, Steven Seagal. As a result of his negative experiences during filming, Connery became unhappy with the major studios and did not make any films for two years. Following the successful European production The Name of the Rose (1986), for which he won a BAFTA Award for Best Actor, Connery's interest in more commercial material was revived. That same year, a supporting role in Highlander showcased his ability to play older mentors to younger leads, which became a recurring role in many of his later films.

In 1987, Connery starred in Brian De Palma's The Untouchables, where he played a hard-nosed Irish-American cop alongside Kevin Costner's Eliot Ness. The film also starred Charles Martin Smith, Patricia Clarkson, Andy Garcia, and Robert De Niro as Al Capone. The film was a critical and box office success. Many critics praised Connery for his performance including Roger Ebert who wrote "The best performance in the movie is Connery... [he] brings a human element to his character; he seems to have had an existence apart from the legend of the Untouchables, and when he's onscreen we can believe, briefly, that the Prohibition Era was inhabited by people, not caricatures." For his performance Connery received the Academy Award for Best Supporting Actor.

Connery starred in Steven Spielberg's Indiana Jones and the Last Crusade (1989), playing Henry Jones, Sr., the title character's father, and received BAFTA and Golden Globe Award nominations. Harrison Ford stated that Connery’s contributions at the writing stage enhanced the film. "It was amazing for me in how far he got into the script and went after exploiting opportunities for character. His suggestions to George [Lucas] at the writing stage really gave the character and the picture a lot more complexity and value than it had in the original screenplay." His subsequent box-office hits included The Hunt for Red October (1990), The Russia House (1990), The Rock (1996), and Entrapment (1999). In 1996, he voiced the role of Draco the dragon in the film Dragonheart. He also appeared in a brief cameo as King Richard the Lionheart at the end of Robin Hood: Prince of Thieves (1991). In 1998, Connery received the BAFTA Fellowship, a lifetime achievement award from the British Academy of Film and Television Arts.

Connery's later films included several box office and critical disappointments such as First Knight (1995), Just Cause (1995), The Avengers (1998), and The League of Extraordinary Gentlemen (2003); he received positive reviews for his performance in Finding Forrester (2000). He also received a Crystal Globe for outstanding artistic contribution to world cinema. In a 2003 poll conducted by Channel 4 Connery was ranked eighth on their list of the 100 Greatest Movie Stars. The failure of The League of Extraordinary Gentlemen was especially frustrating for Connery, who sensed during shooting that the production was "going off the rails" announced that the director, Stephen Norrington should be "locked up for insanity", and spent considerable effort in trying to salvage the film through the editing process, ultimately deciding to retire from acting rather than go through such stress ever again.

Connery was offered the role of Gandalf in The Lord of the Rings series but declined it, claiming he did not understand the script. Connery was reportedly offered $30 million along with 15 percent of the worldwide box office receipts for the role, which – had he accepted – would have earned him $450 million. Connery also turned down the opportunity to appear as the Architect in The Matrix trilogy for similar reasons. Connery's disillusionment with the "idiots now making films in Hollywood" was cited as a reason for his eventual decision to retire from film-making. In 2005, he recorded voiceovers for a new video game version of his Bond film From Russia with Love. In an interview on the game disc, Connery stated that he was very happy that the producers of the game (EA Games) had approached him to voice Bond. It was recorded by Terry Manning in the Bahamas, as well as his likeness, and those of several of the film's supporting cast.

Retirement

When Connery received the American Film Institute's Lifetime Achievement Award on 8 June 2006, he confirmed his retirement from acting. On 7 June 2007, he denied rumours that he would appear in the fourth Indiana Jones film, stating that "retirement is just too much damned fun". In 2010, a bronze bust sculpture of Connery was placed in Tallinn, the capital of Estonia. The work is located outside Tallinn's Scottish Club, whose membership includes Estonian Scotophiles and a handful of expatriate Scots. Connery briefly came out of retirement in 2012 by voice acting the title character in the animated movie Sir Billi the Vet. Connery served as executive producer for an expanded 80-minute version.

Death

Connery died in his sleep on 31 October 2020, aged 90, at his home in Nassau in the Bahamas. His death was announced by his family and Eon Productions that same day. His son Jason stated that he "had been unwell for some time"

                                 https://en.wikipedia.org/wiki/Sean_Connery

Friday, October 30, 2020

Earth-Sized Rogue Planet in the Milky Way

Our Galaxy may be teeming with rogue planets, gravitationally unbound to any star. An international team of scientists, led by Polish astronomers, has announced the discovery of the smallest Earth-sized free-floating planet found to date.

From the Astronomical Observatory of the University of Warsaw

October 29, 2020 -- Over four thousand extrasolar planets have been discovered to date. Although many of the known exoplanets do not resemble those in our solar system, they have one thing in common – they all orbit a star. However, theories of planet formation and evolution predict the existence of free-floating (rogue) planets, gravitationally unattached to any star. Indeed, a few years ago Polish astronomers from the OGLE team from the Astronomical Observatory of the University of Warsaw provided the first evidence for the existence of such planets in the Milky Way. Writing in Astrophysical Journal Letters, OGLE astronomers announced the discovery of the smallest rogue planet found to date.

Exoplanets can be only rarely directly observed. Usually, astronomers find planets using observations of the light from the planet’s host star. For example, if a planet crosses in front of its parent star’s disk, then the observed brightness of the star periodically drops by a small amount causing so called transits. Astronomers can also measure the motion of the star caused by the planet.

Free-floating planets emit virtually no radiation and – by definition – they do not orbit any host star, so they cannot be discovered using traditional methods of astrophysical detection. Nevertheless, rogue planets can be spotted using an astronomical phenomenon called gravitational microlensing. Microlensing results from Einstein's theory of general relativity – a massive object (the lens) may bend the light of a bright background object (the source). The lens’ gravity acts as a huge magnifying glass which bends and magnifies the light of distant stars.

If a massive object (a star or a planet) passes between an Earth-based observer and a distant source star, its gravity may deflect and focus light from the source. The observer will measure a short brightening of the source star – explains dr Przemek Mróz, a postdoctoral scholar at the California Institute of Technology and a lead author of the study. Chances of observing microlensing are extremely slim because three objects – source, lens, and observer – must be nearly perfectly aligned. If we observed only one source star, we would have to wait almost a million year to see the source being microlensed – he adds.

This is why modern surveys hunting for gravitational microlensing events are monitoring hundreds of millions of stars in the Milky Way center, where the chances of microlensing are highest. The OGLE survey – led by Warsaw University astronomers – carries out one of such experiments. OGLE is one of the largest and longest sky surveys, it started operations over 28 years ago. Currently, OGLE astronomers are using a 1.3-meter Warsaw Telescope located at Las Campanas Observatory, Chile. Each clear night, they point their telescope to the central regions of the Galaxy and observe hundreds of millions of stars, searching for those which change their brightness.

Gravitational microlensing does not depend on the lens’ brightness, so it enables the study of faint or dark objects such as planets. Duration of microlensing events depends on the mass of the lensing object – the less massive the lens, the shorter the microlensing event. Most of the observed events, which typically last several days, are caused by stars. Microlensing events attributed to free-floating planets have timescales of barely a few hours. By measuring the duration of a microlensing event (and shape of its light curve) we can estimate the mass of the lensing object.

The scientists announced the discovery of the shortest-timescale microlensing event ever found, called OGLE-2016-BLG-1928, which has the timescale of just 42 minutes. When we first spotted this event, it was clear that it must have been caused by an extremely tiny object –says dr Radosław Poleski from the Astronomical Observatory of the University of Warsaw, a co-author of the study. Indeed, models of the event indicate that the lens must have been less massive than Earth, it was probably a Mars-mass object. Moreover, the lens is likely a rogue planet. If the lens were orbiting a star, we would detect its presence in the light curve of the event – adds dr Poleski. We can rule out the planet having a star within about 8 astronomical units (the astronomical unit is the distance between the Earth and the Sun).

OGLE astronomers provided the first evidence for a large population of rogue planets in the Milky Way a few years ago. However, the newly-detected planet is the smallest rogue world ever found. Our discovery demonstrates that low-mass free-floating planets can be detected and characterized using ground-based telescopes – says Prof. Andrzej Udalski, the PI of the OGLE project.

Astronomers suspect that free-floating planets actually formed in protoplanetary disks around stars (as “ordinary” planets) and they have been ejected from their parent planetary systems after gravitational interactions with other bodies, for example, with other planets in the system. Theories of planet formation predict that the ejected planets should be typically smaller than Earth. Thus studying free-floating planets enables us to understand the turbulent past of young planetary systems, such as our solar system.

The search for free-floating planets is one of the science drivers of the Nancy Grace Roman Space Telescope, which is currently being constructed by NASA. The observatory is scheduled to start operations in the mid-2020s.

Because of the brevity of the event, additional observations collected by the Korea Microlensing Telescope Network (KMTNet) were needed to characterize the event. KMTNet operates a network of three telescopes – in Chile, Australia, and South Africa.

The discovery would be impossible without long-term observations conducted by the OGLE sky survey. The project is among the largest and longest sky surveys, it started operations over 28 years ago. One of the first goals of the OGLE survey was searching for and studying dark matter using the gravitational microlensing technique. Current studies cover a large range of topics – searching for exoplanets, studying the structure and evolution of the Milky Way and neighboring galaxies, studies of variable stars, quasars, transients, and solar system bodies.

https://www.fuw.edu.pl/press-release/news6616.html

Thursday, October 29, 2020

What Is a Poultice?

How Can I Use It to Relieve Inflammation?

by Adrienne Santos Longhurst 

Medically reviewed by Gerhard Whitworth, R.N.

May 17, 2019 – A poultice, also called a cataplasm, is a paste made of herbs, plants, and other substances with healing properties. The paste is spread on a warm, moist cloth and applied to the body to relieve inflammation and promote healing. Some can be spread directly on the skin.

This popular home remedy has been used for centuries to treat inflammation, insect bites, and more.

Poultice benefits and uses

When using a poultice, you not only get the benefits of the ingredients used, but the method itself. The warm poultice increases blood flow to the area, which is an important part of healing.

Poultice for abscess

An abscess, also called a boil, is a collection of pus that forms due to a bacterial infection. A poultice has been a popular home remedy for the treatment for abscesses for centuries. The moist heat from a poultice can help to draw out the infection and help the abscess shrink and drain naturally.

An Epsom salt poultice is a common choice for treating abscesses in humans and animals. Epsom salt helps to dry out the pus and cause the boil to drain.

Poultice for infection

A poultice can treat infection by killing bacteria and drawing out the infection. The use of poultices made of herbs, mud, or clay for infection is ancient.

Recently, researchers discoveredTrusted Source that a poultice made of OMT Blue Clay may help fight certain types of disease-causing bacteria when applied to wounds. This included some treatment-resistant bacteria.

Poultice for cyst

cyst is a sac filled with fluid or a mix of solid substances and fluids. They can grow anywhere on your body or under your skin and range in size, depending on the type.

Applying a warm poultice to a cyst can speed up healing by helping it drain.

Poultice for diabetic ulcer

There is evidence of the effectiveness of poultices for diabetic ulcers dating back to the late 1800s. At the time, a poultice containing linseed was used to soften calluses before cutting away the diseased tissue and applying antiseptic.

More recently, a 2016 animal study suggested that a poultice made from the fern Blechnum orientale could be an effective treatment for diabetic ulcers. More research is needed to understand its effects in humans.

Poultice for arthritis

You may remember a grandparent or great-grandparent smothering a homemade paste over their knee for arthritis. Using herbs for arthritis is a practice that continues to this day.

2010 studyTrusted Source on 10 adults with osteoarthritis found that applying a warm ginger compress to the kidney area improved pain and stiffness, as well as overall well-being.

Ginger and a number of other plants have been shownTrusted Source to have anti-arthritic, anti-rheumatic, and anti-inflammation properties. Applying a poultice made of herbs for arthritis pain may help relieve inflammation and pain.

Which herbs and other ingredients work best?

You have a few options when it comes to ingredients for making poultices. Which will work best depends on what you’re treating.

Herbs

The following are herbs with medicinal properties that can be used to make poultices for a variety of ailments, such as minor skin irritations or abrasions:

Other ingredients

Other popular ingredients for a DIY poultice include:

Precautions for using a poultice

An allergic reaction is possible when applying any substance directly on your skin. Test a small area on your forearm before applying the poultice to the affected area.

If you’re applying a poultice to an open wound, be sure to use a clean cloth if making a compress. Do not apply any type of paste or cloth poultice to a wound that appears to be seriously infected.

If you’re making a heated poultice, it should be warm — not hot — to avoid burning your skin.

How to make a poultice

You may get relief from a homemade poultice for things such as minor skin irritations or cuts, bruises, or mild pain from arthritis or a minor injury.

Herbal poultice

Here’s how to make an herbal poultice that can be used to relieve minor inflammation, abrasions, and more.

What you’ll need:

  • 1 teaspoon turmeric powder
  • 1 ounce freshly chopped or grated ginger
  • ¼ small raw sliced onion
  • 1 chopped garlic clove
  • 2 teaspoons coconut oil
  • cheesecloth or cotton bandage

How to do it:

  1. Add the coconut oil followed by the rest of the ingredients to a pan on low heat and allow it to heat until it’s almost dry — but not burnt.
  2. Turn off stove and transfer ingredients to a bowl to cool so that it’s warm to the touch.
  3. Lay the cloth flat and add the mixture to the center of the cloth.
  4. Fold the cloth over twice to create a pack or gather it and tie with some string or a rubber band to create a handle — whatever you prefer as long as the ingredients stay inside the cloth.
  5. Place on the affected area for 20 minutes.

Bread poultice

Try a bread poultice on an abscess, cyst, or a splinter. All you need is a slice of bread and 2 or 3 tablespoons of milk. Here’s how to make it:

  1. Warm the milk in a small pan on low heat.
  2. Turn off the stove, remove the pan from heat, and let it cool so it’s warm to the touch — not too hot.
  3. Place the slice of bread in the pan and let it soften.
  4. Stir the milk and bread to make a paste.
  5. Apply the paste to the skin and leave on for 15 minutes.
  6. Repeat two or three times a day.

Baking soda poultice

A baking soda poultice requires nothing more than 2 or 3 tablespoons of baking soda mixed with just enough cold water to make a paste. Apply the paste to minor skin irritations, such as razor burn or mild sunburn, for a cooling effect.

Activated charcoal poultice

A poultice of activated charcoal may help with the inflammation caused by a bug bite or sting, or other minor skin irritation.

To make one:

  • Combine a teaspoon of activated charcoal powder with just enough water to wet the powder to create a paste.
  • Spread the paste on the affected area.
  • Leave on for 10 minutes.
  • Carefully wash off with a damp cloth.
  • Repeat twice a day until healed.

When to see a doctor

See a doctor if your symptoms don’t improve after a week or if you have signs of a serious infection, such as cellulitis. These include:

If you notice an area of redness on your skin that’s expanding quickly or if you have a high fever, go to the nearest emergency room.

Takeaway

Many of the ingredients needed to make a poultice for inflammation are already in your kitchen or bathroom. Just mix with them a bit of water or coconut oil to make a poultice and apply.

Sources

 
Bernhardt M. (2014). Treatment of chronic ulcers of the leg with frog flesh poultice.
10.1001/jamadermatol.2014.384

  Caflischa M, et al. (2018). Antibacterial activity of reduced iron clay against pathogenic bacteria associated with wound infections. DOI:
10.1016/j.ijantimicag.2018.07.018

  Choudhary M, et al. (2015). Medicinal plants with potential anti-arthritic activity. DOI:
10.5455/jice.20150313021918

  Lai J C-Y, et al. (2016). Treatment for diabetic ulcer wounds using a fern tannin optimized hydrogel formulation with antibacterial and antioxidative properties. DOI:
10.1016/j.jep.2016.05.032

  Naves CCLM. (2016). The diabetic foot: A historical overview and gaps in current treatment. DOI:
10.1089/wound.2013.0518

  Therkleson T. (2010). Ginger compress therapy for adults with osteoarthritis. DOI:
10.1111/j.1365-2648.2010.05355.x

                             https://www.healthline.com/health/poultice#summary

Wednesday, October 28, 2020

Cancer Treatment Without Side Effects

University of California at Irvine and Swiss researchers eliminate brain tumors without damaging cognition

October 27, 2020

Irvine, California -- Treating cancer without debilitating side effects has long been the holy grail of oncologists, and researchers at the University of California, Irvine and Switzerland’s Lausanne University Hospital/University of Lausanne (CHUV/UNIL) may have found it.

Charles Limoli, professor of radiation oncology at UCI, and Marie-Catherine Vozenin, associate professor of radiation oncology at CHUV/UNIL, used an ultra-high dose rate of radiation therapy to eliminate brain tumors in mice, bypassing key side effects usually caused by cranial irradiation. Their findings are published in Clinical Cancer Research.

“It’s not unreasonable to expect that in 10 years, this may become a widespread option for radiotherapy patients worldwide,” Limoli said.

Traditional radiation therapy exposes a tumor and nearby normal tissue to radiation for several minutes at a time, but FLASH radiation therapy (FLASH-RT) allows delivery of the same dose in only tenths of seconds. The speed eliminates many of the toxicities that normally plague cancer survivors long after radiation treatments, significantly decreasing side effects such as inflammation and impairments to cognition.

As in traditional radiation therapy, the researchers fractionated the dose – divided the total over several sessions. Using FLASH-RT, they found that the same total dose of radiation delivered at quicker dose rates removed brain tumors just as effectively as the traditional method.

“This is very important, since fractionation is the standard in the clinic and the easiest way to transfer FLASH-RT at the clinical level,” said principal investigator Vozenin, an adjunct professor at UCI.

Though this work focused on the brain, FLASH-RT has also been used to treat lung, skin and intestinal cancers, while still preventing many radiation-induced complications. These additional studies have been successful across several types of animals, including fish, mice, pigs, cats and one human subject.

“It seems that this treatment is going to be universally beneficial for most cancer types,” Limoli said.

Now that researchers have verified that the method works, groups around the world are developing machines that would make FLASH technology available in clinics. One device is awaiting approval in the U.S. and Europe, and Vozenin plans to use it in two clinical trials at CHUV early next year.

Meanwhile, she and Limoli are investigating the mechanisms behind FLASH-RT’s beneficial effects to better understand how the technology works.

Said Limoli: “In the last 30 or 40 years, I’d say, there’s been nothing in the field of radiation sciences as exciting as this.”

              https://news.uci.edu/2020/10/27/cancer-treatment-without-side-effects/

Tuesday, October 27, 2020

Scientists Voice A.I. Concerns

Call for transparency and reproducibility in A.I. research

From multiple academic institutions

October 14, 2020 -- International scientists are challenging their colleagues to make Artificial Intelligence (AI) research more transparent and reproducible to accelerate the impact of their findings for cancer patients.

In an article published in Nature on October 14, 2020, scientists at Princess Margaret Cancer Centre, University of Toronto, Stanford University, Johns Hopkins, Harvard School of Public Health, Massachusetts Institute of Technology, and others, challenge scientific journals to hold computational researchers to higher standards of transparency, and call for their colleagues to share their code, models and computational environments in publications.

"Scientific progress depends on the ability of researchers to scrutinize the results of a study and reproduce the main finding to learn from," says Dr. Benjamin Haibe-Kains, Senior Scientist at Princess Margaret Cancer Centre and first author of the article. "But in computational research, it's not yet a widespread criterion for the details of an AI study to be fully accessible. This is detrimental to our progress."

The authors voiced their concern about the lack of transparency and reproducibility in AI research after a Google Health study by McKinney et al., published in a prominent scientific journal in January 2020, claimed an artificial intelligence (AI) system could outperform human radiologists in both robustness and speed for breast cancer screening. The study made waves in the scientific community and created a buzz with the public, with headlines appearing in BBC News, CBC, CNBC.

A closer examination raised some concerns: the study lacked a sufficient description of the methods used, including their code and models. The lack of transparency prohibited researchers from learning exactly how the model works and how they could apply it to their own institutions.

"On paper and in theory, the McKinney et al. study is beautiful," says Dr. Haibe-Kains, "But if we can't learn from it then it has little to no scientific value."

According to Dr. Haibe-Kains, who is jointly appointed as Associate Professor in Medical Biophysics at the University of Toronto and affiliate at the Vector Institute for Artificial Intelligence, this is just one example of a problematic pattern in computational research.

"Researchers are more incentivized to publish their finding rather than spend time and resources ensuring their study can be replicated," explains Dr. Haibe-Kains. "Journals are vulnerable to the 'hype' of AI and may lower the standards for accepting papers that don't include all the materials required to make the study reproducible -- often in contradiction to their own guidelines."

This can actually slow down the translation of AI models into clinical settings. Researchers are not able to learn how the model works and replicate it in a thoughtful way. In some cases, it could lead to unwarranted clinical trials, because a model that works on one group of patients or in one institution, may not be appropriate for another.

In the article titled Transparency and reproducibility in artificial intelligence, the authors offer numerous frameworks and platforms that allow safe and effective sharing to uphold the three pillars of open science to make AI research more transparent and reproducible: sharing data, sharing computer code and sharing predictive models.

"We have high hopes for the utility of AI for our cancer patients," says Dr. Haibe-Kains. "Sharing and building upon our discoveries -- that's real scientific impact."

Story Source:

Materials provided by University Health Network

                      https://www.sciencedaily.com/releases/2020/10/201014114606.htm

Monday, October 26, 2020

What Is "Abductive Reasoning"?

Abductive reasoning (also called abduction, abductive inference, or retroduction) is a form of logical inference formulated and advanced by American philosopher Charles Sanders Peirce beginning in the last third of the 19th century. It starts with an observation or set of observations and then seeks to find the simplest and most likely conclusion from the observations. This process, unlike deductive reasoning, yields a plausible conclusion but does not positively verify it. Abductive conclusions are thus qualified as having a remnant of uncertainty or doubt, which is expressed in retreat terms such as "best available" or "most likely". One can understand abductive reasoning as inference to the best explanation, although not all usages of the terms abduction and inference to the best explanation are exactly equivalent.

In the 1990s, as computing power grew, the fields of law, computer science, and artificial intelligence research spurred renewed interest in the subject of abduction. Diagnostic expert systems frequently employ abduction.

Deduction, Induction and Abduction

Deduction

Deductive reasoning allows deriving b from a only where b is a formal logical consequence of a.  In other words, deduction derives the consequences of the assumed. Given the truth of the assumptions, a valid deduction guarantees the truth of the conclusion. For example, given that "Wikis can be edited by anyone" (a1) and "Wikipedia is a wiki" (a2), it follows that "Wikipedia can be edited by anyone."

Induction

Inductive reasoning allows inferring b from a, where b does not follow necessarily from a. might give us very good reason to accept b, but it does not ensure b.  For example, if all swans that we have observed so far are white, we may induce that the possibility that all swans are white is reasonable. We have good reason to believe the conclusion from the premise, but the truth of the conclusion is not guaranteed. (Indeed, it turns out that some swans are black.)

Abduction

Abductive reasoning allows inferring a as an explanation of b. As a result of this inference, abduction allows the precondition a to be abduced from the consequence b. Deductive reasoning and abductive reasoning thus differ in the direction in which a rule like "a entails b” is used for inference.

As such, abduction is formally equivalent to the logical fallacy of affirming the consequent (or post hoc ergo propter hoc) because of multiple possible explanations for b.  For example, in a billiard game, after glancing and seeing the eight ball moving towards us, we may abduce that the cue ball struck the eight ball. The strike of the cue ball would account for the movement of the eight ball. It serves as a hypothesis that explains our observation. Given the many possible explanations for the movement of the eight ball, our abduction does not leave us certain that the cue ball in fact struck the eight ball, but our abduction, still useful, can serve to orient us in our surroundings. Despite many possible explanations for any physical process that we observe, we tend to abduce a single explanation (or a few explanations) for this process in the expectation that we can better orient ourselves in our surroundings and disregard some possibilities. Properly used, abductive reasoning can be a useful source of priors in Bayesian statistics.

Introduction and Development of Abduction by Peirce

The American philosopher Charles Sanders Peirce introduced abduction into modern logic. Over the years he called such inference hypothesisabductionpresumption, and retroduction. He considered it a topic in logic as a normative field in philosophy, not in purely formal or mathematical logic, and eventually as a topic also in economics of research.

As two stages of the development, extension, etc., of a hypothesis in scientific inquiry, abduction and also induction are often collapsed into one overarching concept — the hypothesis. That is why, in the scientific method known from Galileo and Bacon, the abductive stage of hypothesis formation is conceptualized simply as induction. Thus, in the twentieth century this collapse was reinforced by Karl Popper's explication of the hypothetico-deductive model, where the hypothesis is considered to be just "a guess" (in the spirit of Peirce). However, when the formation of a hypothesis is considered the result of a process it becomes clear that this "guess" has already been tried and made more robust in thought as a necessary stage of its acquiring the status of hypothesis. Indeed, many abductions are rejected or heavily modified by subsequent abductions before they ever reach this stage.

Before 1900, Peirce treated abduction as the use of a known rule to explain an observation. For instance: it is a known rule that, if it rains, grass gets wet; so, to explain the fact that the grass on this lawn is wet, one abduces that it has rained. Abduction can lead to false conclusions if other rules that might explain the observation are not taken into account—e.g. the grass could be wet from dew. This remains the common use of the term "abduction" in the social sciences and in artificial intelligence.

Peirce consistently characterized it as the kind of inference that originates a hypothesis by concluding in an explanation, though an unassured one, for some very curious or surprising (anomalous) observation stated in a premise. As early as 1865 he wrote that all conceptions of cause and force are reached through hypothetical inference; in the 1900s he wrote that all explanatory content of theories is reached through abduction. In other respects Peirce revised his view of abduction over the years.

In later years his view came to be:

  • Abduction is guessing. It is "very little hampered" by rules of logic. Even a well-prepared mind's individual guesses are more frequently wrong than right. But the success of our guesses far exceeds that of random luck and seems born of attunement to nature by instinct (some speak of intuition in such contexts).
  • Abduction guesses a new or outside idea so as to account in a plausible, instinctive, economical way for a surprising or very complicated phenomenon. That is its proximate aim.
  • Its longer aim is to economize inquiry itself. Its rationale is inductive: it works often enough, is the only source of new ideas, and has no substitute in expediting the discovery of new truths. Its rationale especially involves its role in coordination with other modes of inference in inquiry. It is inference to explanatory hypotheses for selection of those best worth trying.
  • Pragmatism is the logic of abduction. Upon the generation of an explanation (which he came to regard as instinctively guided), the pragmatic maxim gives the necessary and sufficient logical rule to abduction in general. The hypothesis, being insecure, needs to have conceivable implications for informed practice, so as to be testable and, through its trials, to expedite and economize inquiry. The economy of research is what calls for abduction and governs its art.

Writing in 1910, Peirce admits that "in almost everything I printed before the beginning of this century I more or less mixed up hypothesis and induction" and he traces the confusion of these two types of reasoning to logicians' too "narrow and formalistic a conception of inference, as necessarily having formulated judgments from its premises."

He started out in the 1860s treating hypothetical inference in a number of ways which he eventually peeled away as inessential or, in some cases, mistaken:

  • as inferring the occurrence of a character (a characteristic) from the observed combined occurrence of multiple characters which its occurrence would necessarily involve; for example, if any occurrence of A is known to necessitate occurrence of B, C, D, E, then the observation of B, C, D, E suggests by way of explanation the occurrence of A. (But by 1878 he no longer regarded such multiplicity as common to all hypothetical inference. Wikisource)
  • as aiming for a more or less probable hypothesis (in 1867 and 1883 but not in 1878; anyway by 1900 the justification is not probability but the lack of alternatives to guessing and the fact that guessing is fruitful; by 1903 he speaks of the "likely" in the sense of nearing the truth in an "indefinite sense"; by 1908 he discusses plausibility as instinctive appeal.) In a paper dated by editors as circa 1901, he discusses "instinct" and "naturalness", along with the kind of considerations (low cost of testing, logical caution, breadth, and incomplexity) that he later calls methodeutical.
  • as induction from characters (but as early as 1900 he characterized abduction as guessing)
  • as citing a known rule in a premise rather than hypothesizing a rule in the conclusion (but by 1903 he allowed either approach)
  • as basically a transformation of a deductive categorical syllogism (but in 1903 he offered a variation on modus ponens instead, and by 1911 he was unconvinced that any one form covers all hypothetical inference).

Applications

Abduction can be utilized in artificial intelligence, medicine, automated planning, intelligence analysis, belief revision, philosophy of science, historical linguistics, applied linguistics, anthropology, and computer programming.

Related Concepts and Persons

                                         https://en.wikipedia.org/wiki/Abductive_reasoning

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Footnote by the Blog Author

It appears that abduction is a critical element in important areas of decision making such as games of incomplete information (such as poker, contract bridge and Bayesian games), as well as  asymmetric warfare, troubleshooting, and forecasting.