Sunday, January 31, 2021

Upgrading Plastic Bottles to Higher Value

From: American Chemical Society

January 27, 2021 -- Plastic is ubiquitous in people's lives. Yet, when plastic-containing items have fulfilled their missions, only a small amount is recycled into new products, which are often of lower quality compared to the original material. And, transforming this waste into high-value chemicals requires substantial energy. Now, researchers reporting in ACS' JACS Au have combined a ruthenium-carbon catalyst and mild, lower-energy reaction conditions to convert plastics used in bottles and other packaging into fuels and chemical feedstock.

Global production of sturdy, single-use plastic for toys, sterile medical packaging, and food and beverage containers is increasing. Polyolefin polymers, such as polyethylene and polypropylene, are the most common plastics used in these products because the polymers' molecular structures -- long, straight chains of carbon and hydrogen atoms -- make materials very durable. It's difficult to degrade the carbon-to-carbon bonds in polyolefins, however, so energy-intensive procedures using high temperatures, from 800 to 1400 F, or strong chemicals are needed to break down and recycle them. Previous studies have shown that noble metals, such as zirconium, platinum and ruthenium, can catalyze the process of splitting apart short, simple hydrocarbon chains and complicated, plant-based lignin molecules at moderate reaction temperatures requiring less energy than other techniques. So, Yuriy Román-Leshkov and colleagues wanted to see if metal-based catalysts would have a similar effect on solid polyolefins with long hydrocarbon chains, disintegrating them into usable chemicals and natural gas.

The researchers developed a method to react simple hydrocarbon chains with hydrogen in the presence of noble- or transition-metal nanoparticles under mild conditions. In their experiments, ruthenium-carbon nanoparticles converted over 90% of the hydrocarbons into shorter compounds at 392 F. Then, the team tested the new method on more complex polyolefins, including a commercially available plastic bottle. Despite not pretreating the samples, as is necessary with current energy-intensive methods, they were completely broken down into gaseous and liquid products using this new method. In contrast to current degradation methods, the reaction could be tuned so that it yielded either natural gas or a combination of natural gas and liquid alkanes. The researchers say implementing their method could help reduce the volume of post-consumer waste in landfills by recycling plastics to desirable, highly valuable alkanes, though technology to purify the products is needed to make the process economically feasible.

       https://www.sciencedaily.com/releases/2021/01/210127140002.htm 

Saturday, January 30, 2021

Designing Aircraft to Handle Turbulence

Engineers make it possible to simulate complete 'dance' of colliding vortices at reduced computational time

From Perdue University

January 21, 2021 -- To help build aircraft that can better handle violent turbulence, researchers developed a new model that allows engineers to incorporate the physics of an entire vortex collision into their design codes.

In 2018, passengers onboard a flight to Australia experienced a terrifying 10-second nosedive when a vortex trailing their plane crossed into the wake of another flight. The collision of these vortices, the airline suspected, created violent turbulence that led to a free fall.

To help design aircraft that can better maneuver in extreme situations, Purdue University researchers have developed a modeling approach that simulates the entire process of a vortex collision at a reduced computational time. This physics knowledge could then be incorporated into engineering design codes so that the aircraft responds appropriately.

The simulations that aircraft designers currently use capture only a portion of vortex collision events and require extensive data processing on a supercomputer. Not being able to easily simulate everything that happens when vortices collide has limited aircraft designs.

With more realistic and complete simulations, engineers could design aircraft such as fighter jets capable of more abrupt maneuvers or helicopters that can land more safely on aircraft carriers, the researchers said.

"Aircraft in extreme conditions cannot rely on simple modeling," said Carlo Scalo, a Purdue associate professor of mechanical engineering with a courtesy appointment in aeronautics and astronautics.

"Just to troubleshoot some of these calculations can take running them on a thousand processors for a month. You need faster computation to do aircraft design."

Engineers would still need a supercomputer to run the model that Scalo's team developed, but they would be able to simulate a vortex collision in about a tenth to a hundredth of the time using far less computational resources than those typically required for large-scale calculations.

The researchers call the model a "Coherent-vorticity-Preserving (CvP) Large-Eddy Simulation (LES)." The four-year development of this model is summarized in a paper published in the Journal of Fluid Mechanics.

"The CvP-LES model is capable of capturing super complex physics without having to wait a month on a supercomputer because it already incorporates knowledge of the physics that extreme-scale computations would have to meticulously reproduce," Scalo said.

Former Purdue postdoctoral researcher Jean-Baptiste Chapelier led the two-year process of building the model. Xinran Zhao, another Purdue postdoctoral researcher on the project, conducted complex, large-scale computations to prove that the model is accurate. These computations allowed the researchers to create a more detailed representation of the problem, using more than a billion points. For comparison, a 4K ultra high definition TV uses approximately 8 million points to display an image.

Building off of this groundwork, the researchers applied the CvP-LES model to the collision events of two vortex tubes called trefoil knotted vortices that are known to trail the wings of a plane and "dance" when they reconnect.

This dance is extremely difficult to capture.

"When vortices collide, there's a clash that creates a lot of turbulence. It's very hard computationally to simulate because you have an intense localized event that happens between two structures that look pretty innocent and uneventful until they collide," Scalo said.

Using the Brown supercomputer at Purdue for mid-size computations and Department of Defense facilities for large-scale computations, the team processed data on the thousands of events that take place when these vortices dance and built that physics knowledge into the model. They then used their turbulence model to simulate the entire collision dance.

Engineers could simply run the ready-made model to simulate vortices over any length of time to best resemble what happens around an aircraft, Scalo said. Physicists could also shrink the model down for fluid dynamics experiments.

"The thing that's really clever about Dr. Scalo's approach is that it uses information about the flow physics to decide the best tactic for computing the flow physics," said Matthew Munson, program manager for Fluid Dynamics at the Army Research Office, an element of the U.S. Army Combat Capabilities Development Command's Army Research Laboratory.

"It's a smart strategy because it makes the solution method applicable to a wider variety of regimes than many other approaches. There is enormous potential for this to have a real impact on the design of vehicle platforms and weapons systems that will allow our soldiers to successfully accomplish their missions."

Scalo's team will use Purdue's newest community cluster supercomputer, Bell, to continue its investigation of complex vortical flows. The team also is working with the Department of Defense to apply the CvP-LES model to large-scale test cases pertaining to rotorcrafts such as helicopters.

"If you're able to accurately simulate the thousands of events in flow like those coming from a helicopter blade, you could engineer much more complex systems," Scalo said.

        https://www.sciencedaily.com/releases/2021/01/210121131701.htm

Friday, January 29, 2021

Inner Meaning of American "ZIP Codes"

A ZIP Code is a postal code used by the United States Postal Service (USPS). Introduced in 1963, the basic format consisted of five digits. In 1983, an extended ZIP+4 code was introduced; it included the five digits of the ZIP Code, followed by a hyphen and four digits that designated a more specific location.

The term ZIP is an acronym for Zone Improvement Plan; it was chosen to suggest that the mail travels more efficiently and quickly (zipping along) when senders use the code in the postal address. The term ZIP Code was originally registered as a servicemark by the USPS, but its registration expired in 1997.

Early History and Five Digit Zip Codes

The early history and context of postal codes began with postal district/zone numbers. The United States Post Office Department (USPOD) implemented postal zones for many large cities in 1943.

For example:

Mr. John Smith
3256 Epiphenomenal Avenue
Minneapolis 16, Minnesota

The "16" is the number of the postal zone in the specific city.

By the early 1960s, a more organized system was needed, and non-mandatory five-digit ZIP Codes were introduced nationwide on July 1, 1963. The USPOD issued its Publication 59: Abbreviations for Use with ZIP Code on October 1, 1963, with the list of two-letter state abbreviations which are generally written with both letters capitalized.  An earlier list, publicized in June 1963, had proposed capitalized abbreviations ranging from two to five letters.  According to Publication 59, the two-letter standard was "based on a maximum 23-position line, because this has been found to be the most universally acceptable line capacity basis for major addressing systems", which would be exceeded by a long city name combined with a multi-letter state abbreviation, such as "Sacramento, Calif." along with the ZIP Code. The abbreviations have remained unchanged, with the exception of Nebraska, which was changed from NB to NE in 1969 at the request of the Canadian postal administration0, to avoid confusion with the Canadian province of New Brunswick.

Robert Moon is considered the father of the ZIP Code; he submitted his proposal in 1944 while working as a postal inspector.  The post office only credits Moon with the first three digits of the ZIP Code, which describe the sectional center facility (SCF) or "sec center". An SCF is a central mail processing facility with those three digits. The fourth and fifth digits, which give a more precise locale within the SCF, were proposed by Henry Bentley Hahn, Sr.

The SCF sorts mail to all post offices with those first three digits in their ZIP Codes. The mail is sorted according to the final two digits of the ZIP Code and sent to the corresponding post offices in the early morning. Sectional centers do not deliver mail and are not open to the public (although the building may include a post office that is open to the public), and most of their employees work the night shift.  Items of mail picked up at post offices are sent to their own SCFs in the afternoon, where the mail is sorted overnight. In the case of large cities, the last two digits as assigned generally coincided with the older postal zone number.

For example:

Mr. John Smith
3256 Epiphenomenal Avenue
Minneapolis, MN  55416

In 1967, these became mandatory for second- and third-class bulk mailers, and the system was soon adopted generally. The United States Post Office used a cartoon character, which it called Mr. ZIP, to promote the use of the ZIP Code. He was often depicted with a legend such as "USE ZIP CODE" in the selvage of panes of postage stamps or on the covers of booklet panes of stamps.  Mr. ZIP was featured prominently alongside musical group "The Swingin' Six" in a variety show that the post office used to explain the importance of using ZIP codes.

In 1971, Elmira (NY) Star-Gazette reporter Dick Baumbach found out the White House was not using a ZIP Code on its envelopes. Herb Klein, special assistant to President Nixon, responded by saying the next printing of envelopes would include the ZIP Code.

Zip Plus Four Added in 1983

In 1983, the U.S. Postal Service introduced an expanded ZIP Code system that it called ZIP+4, often called "plus-four codes", "add-on codes", or "add-ons". A ZIP+4 Code uses the basic five-digit code plus four additional digits to identify a geographic segment within the five-digit delivery area, such as a city block, a group of apartments, an individual high-volume receiver of mail, a post office box, or any other unit that could use an extra identifier to aid in efficient mail sorting and delivery. However, initial attempts to promote universal use of the new format met with public resistance and today the plus-four code is not required.  In general, mail is read by a multiline optical character reader (MLOCR) that almost instantly determines the correct ZIP+4 Code from the address—along with the even more specific delivery point—and sprays an Intelligent Mail barcode (IM) on the face of the mail piece that corresponds to 11 digits—nine for the ZIP+4 Code and two for the delivery point.

For Post Office Boxes, the general (but not invariable) rule is that each box has its own ZIP+4 code. The add-on code is often one of the following: the last four digits of the box number (e.g. PO Box 107050, Albany, NY 12201-7050), zero plus the last three digits of the box number (e.g., PO Box 17727, Eagle River, AK 99577-0727), or, if the box number consists of fewer than four digits, enough zeros are attached to the front of the box number to produce a four-digit number (e.g., PO Box 77, Juneau, AK 99750-0077). However, there is no uniform rule, so the ZIP+4 Code must be looked up individually for each box (e.g. using the USPS's official ZIP Code Lookup tool, and being sure to enter just city and state, not the 5-digit ZIP).

Postal Bar Code

The ZIP Code is often translated into an Intelligent Mail barcode that is printed on the mailpiece to make it easier for automated machines to sort. A barcode can be printed by the sender (some word-processing programs such as WordPerfect include the feature), but this is not recommended, as the address-to-ZIP lookup tables can be significantly out of date. It is better to let the post office put one on when it processes the piece.  In general, the post office uses OCR [optical character recognition] technology, though in some cases a human might have to read and enter the address.

Customers who send bulk mail can get a discount on postage if they have printed the barcode themselves and have presorted the mail. This requires more than just a simple font; mailing lists must be standardized with up-to-date Coding Accuracy Support System (CASS)-certified software that adds and verifies a full, correct ZIP+4 Code and an additional two digits representing the exact delivery point.  Furthermore, mail must be sorted in a specific manner to an 11-digit code with at least 150 mailpieces for each qualifying ZIP Code and must be accompanied by documentation confirming this. These steps are usually done with PAVE-certified software that also prints the barcoded address labels and the barcoded sack or tray tags.

ZIP Code - Wikipedia

Thursday, January 28, 2021

Very Efficient Grid-Scale Electricity Storage

The new approach can store electricity in these batteries for very long durations for about a fifth the price of current technologies 

From: University of Warwick

January 22, 2021 -- Researchers in WMG at the University of Warwick, in collaboration with Imperial College London, have found a way to enhance hybrid flow batteries and their commercial use. The new approach can store electricity in these batteries for very long durations for about a fifth the price of current technologies, with minimal location restraints and zero emissions.

The researchers enhanced three hybrid flow cells using nitrogen doped graphene (exposed to nitrogen plasma) in a binder-free electrophoresis technique (EPD).

Wind and solar power are increasingly popular sources for renewable energy. Unfortunately, intermittency issues keep them from connecting widely to the National grid. One potential solution to this problem involves in the deployment of long-duration battery technology, such as the redox flow battery. Despite its great promise the current costs of this system are a key determining factor to real-world adoption. An affordable grid battery should cost £75/kWh, according to the US Department of Energy. Lithium-ion batteries, which lead the charge for grid storage, cost about £130/kWh.

Now WMG researchers have found a way of enhancing hybrid flow batteries or regenerative fuel cell (RFC) technology that could store electricity for very long durations for about one-fifth the cost of current storage technologies, with flexibility in siting and with minimal environmental impact. The technology combines carbon-based electrodes with economically sourced electrolytes, (manganese or sulphur, which are abundant chemicals in the planet) by means of a simple and yet highly effective electrophoretic deposition of nano-carbon additives (nitrogen-doped graphene) that enhance the electrode durability and performance significantly in highly acidic or alkaline environments.

The researchers have published their findings in a paper entitled, 'Hybrid Redox Flow Cells with Enhanced Electrochemical Performance via Binderless and Electrophoretically Deposited Nitrogen-Doped Graphene on Carbon Paper Electrodes' in the December 2020 edition of the journal ACS Applied Materials & Interfaces.

Dr Barun Chakrabarti, a Research Fellow in WMG at the University of Warwick and one of the lead authors on the paper said:

"This EPD technique is not only simple but also improves the efficiencies of three different economical hybrid flow batteries thereby increasing their potential for widespread commercial adoption for grid-scale energy storage."

The hybrid flow battery's total chemical cost is about 1/30th the cost of competing batteries, such as lithium-ion systems. Scaled-up technologies may be used to store electricity from wind or solar power, for multiple days to entire seasons, for about £15 to £20 per kilowatt hour. These batteries are also extremely useful for grid-scale load levelling applications as their design is very flexible due to their unique feature of sizing their power independently of their energy.

The energy density of a hybrid flow battery, especially the polysulphide/air system (S-Air), is 500 times higher than pumped hydroelectric storage. It is also so much more compact and can be placed near any renewable generation.

        https://www.sciencedaily.com/releases/2021/01/210122112306.htm

Wednesday, January 27, 2021

Metabolism of Children on a Vegan Diet

Statuses of Vitamins D and A require special attention

From: University of Helsinki

January 21, 2021 --- Researchers report a comprehensive pilot study on the metabolic effects of full vegan diet on young children. The study found vegan children to have remarkably altered metabolism and lower vitamin A and D status compared to children with no special diet.

The study concludes that vegan diet has a broad effect on children's metabolism. Serum biomarker levels for vitamins A and D, cholesterol forms and essential amino acids were significantly lower in children on vegan diet compared to age-adjusted omnivores. In addition, docosahexaenoic acid is absent from vegan diet. The results were recently published in a high-profile international scientific journal EMBO Molecular Medicine.

Vegan diets gain popularity especially among young adults, and through choices of the families vegan diet is becoming more common in young children, too. The motives behind choosing a vegan lifestyle are ecological, ethical and health-related: vegan diets exclude all animal-based products. It is recommended that full vegan diet is always supplemented with vitamin B12, vitamin D and iodine, and based on individual assessment the supplementation for calcium, vitamin B2, iron and zinc may be needed.

Except for vitamin D, the study did not find differences between diet groups in the levels of these nutrients in young children. All of the participated vegan children used regular vitamin B12, and all but one used regular vitamin D and iodine supplementation, indicating that Finnish vegan families are well familiar with the previously known nutritional requirements of vegan diets. However, current nutritional recommendations are based on studies conducted on adult vegans, and previous studies on metabolic effects of vegan diets in children do not exist.

In their recently published article Topi Hovinen, MD, and Liisa Korkalo, PhD, together with the multidisciplinary team led by academy professor Anu Suomalainen-Wartiovaara and docent Maijaliisa Erkkola studied comprehensively the nutrition and metabolism of 40 healthy children in daycares of Helsinki. The children were following a vegan, vegetarian or omnivore diet according to the choice of their families. Their nutritional intake, metabolic biomarkers and micronutrient statuses were extensively studied.

The children on a fully vegan diet were found to have significantly lower vitamin D levels compared to children without a special diet despite having regular vitamin D supplementation and blood samples being collected in late summer. Surprisingly, also their vitamin A status was lowered. Levels for LDL and HDL cholesterol, essential amino acid and docosahexaenoic acid, a fatty acid with a central role in development of visual function, were low while folate levels were remarkably high in vegan children.

According to the researchers, the new findings motivate further and larger studies on the health consequences of a vegan diet in young children.

"Our results indicate that the health effects of strict diets on children cannot be extrapolated from studies on adults. In addition to vitamin D intake, attention must be paid to adequate intake of vitamin A and protein from various sources." says Topi Hovinen.

"The vegan families were active to participate in our study. This is important, because without such voluntary contribution of the families it is not possible to undertake this kind of studies," emphasizes Liisa Korkalo.

          https://www.sciencedaily.com/releases/2021/01/210121132300.htm

Tuesday, January 26, 2021

January 2021 Protests in Russia

Protests began in Russia on 23 January 2021 in support of the arrested opposition leader Alexei Navalny and following the release of the film Palace for Putin, which revolves around the connection between President Vladimir Putin and a palace allegedly being built for him. According to the BBC Russian Service, protests were held in 122 towns and cities in Russia.

Background: Poisoning of Alexei Navalny

Navalny had been hospitalized on 20 August 2020, in serious condition after he was poisoned with a Novichok nerve agent during a flight from Tomsk to Moscow.  He was medically evacuated to Berlin and discharged on 22 September.  The use of a Novichok nerve agent was confirmed by the Organisation for the Prohibition of Chemical Weapons (OPCW).  Though the Kremlin denied involvement in his poisoning, the EU and the UK responded by imposing sanctions on six senior Russian officials and a state chemical centre.  Navalny accused President Vladimir Putin of being responsible for his poisoning.  An investigation by Bellingcat and The Insider implicated agents from the Federal Security Service (FSB) in Navalny's poisoning.

Navalny returned to Russia on 17 January 2021, where he was immediately detained on accusations of violating terms of a suspended jail sentence.  Prior to his return, the Federal Penitentiary Service (FSIN) said that Navalny may face jail time upon his arrival in Moscow for violating the terms of his probation, saying it would be "obliged" to detain him once he returned; in 2014, Navalny received a suspended sentence in the Yves Rocher case, which he called politically motivated and in 2017, the European Court of Human Rights ruled that Navalny was unfairly convicted.  The Investigative Committee of Russia also said that it was investigating Navalny for alleged fraud.  A court decision the next day ordered the detention of Navalny until 15 February for violating his parole. A makeshift court was set up in the police station Navalny was being held. Another hearing would be held on 29 January to determine whether his suspended sentence should be replaced with a jail term.  Navalny described the procedure as “ultimate lawlessness”. He also called on his supporters to take to the streets, saying: “Do not be silent. Resist. Take to the streets — not for me, but for you”. Navalny's regional network head, Leonid Volkov, said that preparations were being made for protests to be organised across the country on 23 January.

While in jail, a video of an investigation by Navalny and his Anti-Corruption Foundation (FBK) was published, accusing Putin of corruption. The video also urged people to take to the streets.  Before the protests had begun, the video received over 60 million views on YouTube.  The video was released on 19 January, and by the next day the state communications watchdog Roskomnadzor was demanding the social networks VKontakte (VK) and TikTok to stop the spread of calls to the protests.  The efficacy of these calls is disputed.

Arrests of several of Navalny’s aides and allies, including Lyubov Sobol, began on 21 January.  Several were jailed or fined, with Sobol being released.  The Ministry of Internal Affairs also threatened to prosecute those spreading calls to join the protests.  The Prosecutor General's Office also ordered the censor, Roskomnadzor, to block access to pages that call for protests.  On 22 January, the Main Directorate of the Ministry of Internal Affairs for Moscow issued a statement warning against calls to the protests or participation in them. It stated that any attempts to hold unauthorized events as well as “provocative actions by the participants” would be regarded as a “threat to public order” and be “immediately suppressed”. Social media networks began removing information about the protests. VK blocked access to a number of pages on the protests, with the pages stating that it was blocked on the requirement of the General Prosecutor’s Office.  Roskomnadzor also stated that VK, Instagram, TikTok and YouTube blocked some content which involved “calls for children to participate in illegal mass events”.  However, Facebook and YouTube have countered this claim. Facebook said it “received requests from the local regulator to restrict access to certain content that calls for protest. Since this content doesn’t violate our Community Standards, it remains on our platform.”

Protests in other Countries

Protests were also held in cities around the world, including Berlin, Munich, Prague, Krakow, Helsinki, London, Tallinn, The Hague, Denver, Vienna, Tel Aviv, Copenhagen, and Tokyo.  

In The Hague, Netherlands, around 250 people gathered at a rally.  In Berlin, Germany, around 1,000 protesters were estimated to have gathered at a rally.  In Copenhagen, Denmark, around 150 people gathered in front of the Russian Embassy.

In Stockholm, Sweden, around 80 people gathered outside the Russian embassy.  In Gothenburg, around 20 people gathered outside the Russian consulate.

In Belgrade, Serbia, around 10 people gathered outside the Church of Saint Sava before the police came because they "violated epidemiological measures".

In Tel Aviv, Israel, around 1,500 to 2,000 people were estimated to have gathered at a rally near the Russian embassy. Due to COVID related restrictions, the crowd was asked to disperse by the organizers. Several hundred demonstrators then moved towards the Russian embassy. Another 600 to 1000 protesters were estimated to have gathered at a rally in Haifa.

In Moldova, there were protests in favor of Navalny but also some protests against him.

                   2021 Russian protests - Wikipedia

Monday, January 25, 2021

New Approach: Monitor Proteins Constantly

A game-changer for patients at risk of rapid health deterioration, such as heart complications, stroke, sepsis and cancer.

From: Monash University

January 25. 2021 -- The research team, led by Dr Simon Corrie from Monash University's Department of Chemical Engineering and the ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, took an antibody that binds EGFR (epidermal growth factor receptor) proteins and engineered it to monitor the concentration of EGFR proteins in serum solutions over time.

Co-authors of the paper, published in ACS Sensors, are Dr Christian Fercher, Dr Martina Jones and Professor Stephen Mahler from The University of Queensland and the Australian Institute for Bioengineering and Nanotechnology.

An inability to detect the growth of EGFR proteins in humans can be associated with the development of a number of tumours, including cancer, as well as the onset of diseases like Alzheimer's.

Using an independent detection mechanism developed by the research team, involving fluorescent dyes, researchers created a biosensor from a well-known antibody that was able to 'read out' changes of the EGFR protein in real-time by monitoring detectable changes in the fluorescence spectra.

The ability to monitor protein biomarker concentrations in body fluids in real-time is invaluable for tracking patients at risk of rapid deterioration, including those requiring personalised drug monitoring or those at high risk of complications arising from critical conditions, like sepsis, heart attack or tumour response to treatment.

No one has been able to engineer an antibody for continuous testing until now.

"All the diagnostic tests that we are familiar with involve sampling something (blood, urine, tissue) at a particular point in time and taking the same to a lab to interrogate it. But for patients suffering from acute conditions, in which time to diagnose and rapid treatment are very important, this traditional diagnostic process is not good enough," Dr Corrie said.

"Monitoring dynamic changes in proteins, for example protein levels increasing or decreasing over time, is likely to provide much more detailed information about a disease or treatment process, but the sensors required to do this don't exist outside of continuous glucose testing for diabetes.

"Our capacity to create antibodies, which bind reversibly to targets and can be 'read out' using fluorescence, means we can develop in vivo sensors. These sensors can monitor the levels of critical biomarkers as they change over time in response to a disease or treatment, rather than just sending a sample to a lab and getting a snapshot in a day or two.

"These biomarkers could include the amount of surface proteins on a cancer cell and whether or not a drug causes them to reduce in size, therefore testing the efficacy of treatment. It can also be used to monitor the concentration of potentially toxic drugs, like some antibiotics."

This discovery was able to engineer an antibody fragment capable of reversibly binding to a protein analyte (scFv) in a chemical solution, while retaining the specificity of the original antibody sequence.

Through their efforts, continuous in vitro monitoring over multiple hours was successfully recorded.

"Work is underway to employ dyes that are much better suited to medical applications," Dr Corrie said.

"In future, we expect that this process will be used to generate a range of biosensors that can monitor protein concentration continuously inside the human body, through a biopharmaceutical process, or in the environment."

           https://www.sciencedaily.com/releases/2021/01/210125094323.htm

Sunday, January 24, 2021

The King of Interviewers Has Died

 Larry King (born Lawrence Harvey Zeiger; November 19, 1933 – January 23, 2021) was an American television and radio host, whose awards included two Peabodys, an Emmy and ten Cable ACE Awards.

King was a WMBM radio interviewer in the Miami area in the 1950s and 1960s, and gained prominence beginning in 1978 as host of The Larry King Show, an all-night nationwide call-in radio program heard on the Mutual Broadcasting System. From 1985 to 2010, he hosted the nightly interview television program Larry King Live on CNN. From 2012 to 2020, he hosted Larry King Now which aired on Hulu, Ora TV, and RT America. He continued to host  Politicking with Larry King, a weekly political talk show which aired weekly on the same two channels from 2013 until his death in 2021.

Miami Radio and Television

A CBS staff announcer, whom King met by chance, suggested he go to Florida which was a growing media market with openings for inexperienced broadcasters. King went to Miami, and after initial setbacks, he gained his first job in radio. The manager of a small station, WAHR (now WMBM) in Miami Beach, hired him to clean up and perform miscellaneous tasks. When one of the station's announcers abruptly quit, King was put on the air. His first broadcast was on May 1, 1957, working as the disc jockey from 9 a.m. to noon.  He also did two afternoon newscasts and a sportscast. He was paid $50 a week.

He acquired the name Larry King when the general manager claimed that Zeiger was too difficult to remember, so minutes before airtime, Larry chose the surname King, which he got from an advertisement in the Miami Herald for King's Wholesale Liquor.  Within two years, he legally changed his name to Larry King.

He began to conduct interviews on a mid-morning show for WIOD, at Pumpernik's Restaurant in Miami Beach.  He would interview whoever walked in. His first interview was with a waiter at the restaurant.  Two days later, singer Bobby Darin, in Miami for a concert that evening, walked into Pumpernik's having heard King's radio show; Darin became King's first celebrity interview guest.

King's Miami radio show brought him local attention. A few years later, in May 1960, he hosted Miami Undercover, airing Sunday nights at 11:30 p.m. on WPST-TV Channel 10 (now WPLG).  On the show, he moderated debates on important local issues of the day.

King credited his success on local television to the assistance of comedian Jackie Gleason, whose national television variety show was being taped in Miami Beach beginning in 1964. "That show really took off because Gleason came to Miami," King said in a 1996 interview he gave when inducted into the Broadcasters' Hall of Fame. "He did that show and stayed all night with me. We stayed till five in the morning. He didn't like the set, so we broke into the general manager's office and changed the set. Gleason changed the set, he changed the lighting, and he became like a mentor of mine."

The Larry King Show

On January 30, 1978, King went national on a nightly Mutual Broadcasting System coast-to-coast broadcast, inheriting the talk show slot that had begun with Herb Jepko in 1975, then followed by "Long John" Nebel in 1977, until his illness and death the following year.  King's Mutual show rapidly developed a devoted audience.

The Larry King Show was broadcast live Monday through Friday from midnight to 5:30 a.m. Eastern Standard Time. King would interview a guest for the first 90 minutes, with callers asking questions that continued the interview for another 90 minutes. At 3 a.m., the Open Phone America segment began, where he allowed callers to discuss any topic they pleased with him, until the end of the program, when he expressed his own political opinions. Many stations in the western time zones carried the Open Phone America portion of the show live, followed by the guest interview on tape delay.

Some of King's regular callers used pseudonyms or were given nicknames by King, such as "The Numbers Guy", "The Chair", "The Portland Laugher",  "The Miami Derelict", and "The Scandal Scooper".  At the beginning, the show had relatively few affiliates, though the number was eventually above 500. King hosted the show until stepping down in 1994.  King occasionally entertained the audience by telling amusing stories from his youth or early broadcasting career.

For its final year, the show was moved to afternoons. After King stepped down, Mutual gave the afternoon slot to David Brenner and Mutual's affiliates were given the option of carrying the audio of King's new CNN evening television program. After Westwood One dissolved Mutual in 1999, the radio simulcast of the CNN show continued until December 31, 2009.

Larry King Live

Larry King Live began on CNN in June 1985. On the show, King hosted a broad range of guests, from figures such as UFO conspiracy theorists and alleged psychics, to prominent politicians and entertainment industry figures, often doing their first or only interview on breaking news stories on his show. After broadcasting his CNN show from 9 to 10 p.m., King then traveled to the studios of the Mutual Broadcasting System to do his radio show, when both shows still aired.

Two of his best remembered interviews involved political figures. In 1992, billionaire Ross Perot announced his presidential bid on the show. In 1993, a debate between Al Gore and Perot became CNN's most-watched segment until 2015.

Unlike many interviewers, King had a direct, non-confrontational approach. His reputation for asking easy, open-ended questions made him attractive to important figures who wanted to state their position while avoiding being challenged on contentious topics. King said that when interviewing authors, he did not read their books in advance, so that he would not know more than his audience.  Throughout his career, King interviewed many of the leading figures of his time. According to CNN, King conducted more than 30,000 interviews in his career.

King also wrote a regular newspaper column in USA Today for almost 20 years, from shortly after that first national newspaper's debut in Baltimore-Washington in 1982 until September 2001.  The column consisted of short "plugs, superlatives and dropped names" but was dropped when the newspaper redesigned its "Life" section.  The column was resurrected in blog form in November 2008 and on Twitter in April 2009.

During his career, he did more than 60,000 interviews.  CNN’s Larry King Live became "the longest-running television show hosted by the same person, on the same network and in the same time slot", and was recognized for it by the Guinness Book of World Records.  He retired in 2010 after taping 6,000 episodes of the show.

King’s Death

On January 2, 2021, it was revealed that King had been hospitalized ten days earlier in a Los Angeles hospital after testing positive for COVID-19.  On January 23, he died at the age of 87 at Cedars-Sinai Medical Center, Los Angeles.

                    https://en.wikipedia.org/wiki/Larry_King

Saturday, January 23, 2021

Yes, Eating Less Meat Is Linked to a Longer Life

By Rui Wang

January 22, 2021 -- High-protein diets are having a moment. In any grocery store you can now buy a protein bowl, pick up a protein box of eggs and nuts for lunch, or snack on a protein bar.

But there’s evidence that restricting which proteins you eat — particularly cutting back on meat — could be important for healthy aging. The surprising reason: it forces the tissues to make hydrogen sulphide (H2S), a gas that’s poisonous if inhaled and smells like rotten eggs, but promotes health inside the body.

As a physiology researcher, I have long been interested in the strange role of H2S in the body. This is not a gas anyone wants around. It stinks, is a component of flatulence, and its toxicity has been linked to at least one mass extinction.

And yet, the body naturally produces small amounts of it as a signalling molecule to act as a chemical messenger. Now, we are starting to understand the link between diet and H2S production.

Diet restrictions that increase longevity

Less can be more when it comes to food. When scientists have put organisms on carefully balanced but restricted diets, these organisms have substantially increased healthy lifespans.

This holds true for yeasts, fruit flies, worms and monkeys. In mice, such diets reduce cancer risk, strengthen the immune system and improve cognitive function.

But because aging and longevity are complex processes, it has been difficult for researchers to pin down the mechanisms at work. Recent studies have shed new light, and it is apparent that H2S plays a crucial role.

Studies since the 1990s have shown that reducing intake of certain sulphur-containing amino acids, the building blocks of proteins, can increase longevity in rats by around 30 per cent. More recently, a collaborative team involving me and led by scientists at Harvard, performed a series of animal studies in which we restricted the intake of two sulphur amino acids — cysteine and methionine — to study what effects this had.

It caused the animals to ramp up production of H2S in their tissues, which triggered a cascade of beneficial effects. These included increased new blood vessel generation, which promotes cardiovascular health, and better resistance to oxidative stress in the liver, which is linked to liver disease.

But it remained to be seen whether similar effects would occur in humans. Earlier this year, a study using data from the 11,576 adults in NHANES III, the U.S. national nutrition survey, delivered evidence that they do. It found that reduced dietary intake of these sulphur amino acids is linked to lower cardiometabolic risk factors, including lower levels of cholesterol and glucose in the blood. Cardiometabolic risk factors are those linked to heart disease, stroke and diabetes.

The upshot of this research is that there’s good evidence that limiting intake of foods containing high levels of sulphur amino acids can reduce the risk of chronic diseases like diabetes and heart disease, and promote healthy aging. In North America, most of us are a long way from achieving this. Because these sulphur amino acids are abundant in meat, dairy and eggs, which feature prominently in our shopping carts, we eat on average 2.5 times our daily requirement of them.

Red meat is particularly high in sulphur amino acids, but fish and poultry white meat also contain a lot (the dark meat has less). Switching to plant-based proteins would help reduce this intake.

Beans, lentils and legumes are good sources of protein that are also low in sulphur amino acids. But beware: soy protein, which is the basis of foods like tofu, is surprisingly high in sulphur amino acids. Meanwhile, vegetables like broccoli contain lots of sulphur but not in amino acid fo

One important caveat is that sulphur amino acids play vital roles in growth, so children should not adopt diets that are low in them.

Other roles for H2S

It might seem odd that a toxic gas can help maintain health, but it may reflect the origins of life on early Earth when the atmosphere was much richer in sulphur gas than it is today. Indeed, we are starting to appreciate how fundamental H2S signalling may be. For example, it has also been shown to reduce inflammation, opening the door to potential new treatments for arthritis or potential use as a painkiller.

The trick is delivering H2S where it’s needed — safely. Several pharmaceutical companies are working on compounds that bind it while in transit through the body, and release it in tiny doses in the tissues. In time, these could be used as preventive measures to support healthy aging. This would be useful because the drawback of a low-sulphur amino acid diet is that humans are notoriously bad at sticking to such plans long-term.

In the lab, we can control experimental diets. In the real world, people snack or grab a burger when they don’t want to cook. If delivery mechanisms can be made reliably and cheaply enough, it could be possible to gain the health effects of increased tissue H2S without dictating what people eat.The Conversation

Rui Wang, Dean, Faculty of Science, York University, Canada

This article is republished from The Conversation under a Creative Commons license. Read the original article.

https://www.realclearscience.com/articles/2021/01/22/a_surprising_reason_eating_less_meat_is_linked_to_a_longer_life_657516.html

Friday, January 22, 2021

More Electric Cars on the Road

Study measures which kinds of infrastructure improvements could lead to wider adoption of clean vehicles.

By David L. Chandler, MIT News Office

January 21, 2021 -- A new study from researchers at MIT uncovers the kinds of infrastructure improvements that would make the biggest difference in increasing the number of electric cars on the road, a key step toward reducing greenhouse gas emissions from transportation.

The researchers found that installing charging stations on residential streets, rather than just in central locations such as shopping malls, could have an outsized benefit. They also found that adding on high-speed charging stations along highways and making supplementary vehicles more easily available to people who need to travel beyond the single-charge range of their electric vehicles could greatly increase the vehicle electrification potential.

The findings are reported today in the journal Nature Energy, in a paper by MIT associate professor of energy studies Jessika Trancik, graduate student Wei Wei, postdoc Sankaran Ramakrishnan, and former doctoral student Zachary Needell SM ’15, PhD ’18.

The researchers developed a new methodology to identify charging solutions that would conveniently fit into people’s daily activities. They used data collected from GPS tracking devices in cars, as well as survey results about people’s daily driving habits and needs, including detailed data from the Seattle area and more general data from the U.S. as a whole. Greatly increasing the penetration of electric cars into the personal vehicle fleet is a central feature of climate mitigation policies at local, state, and federal levels, Trancik says. A goal of this study was “to better understand how to make these plans for rapid vehicle electrification a reality,” she adds.

In deciding how to prioritize different kinds of improvements in vehicle charging infrastructure, she says, “the approach that we took methodologically was to emphasize building a better understanding of people’s detailed energy consuming behavior, throughout the day and year.”

To do that, “we examine how different people are moving from location to location throughout the day, and where they are stopping,” she says. “And from there we’re able to look at when and where they would be able to charge without interrupting their daily travel activities.”

The team looked at both regular daily activities and the variations that occur over the course of a year. “The longitudinal view is important for capturing the different kinds of trips that a driver makes over time, so that we can determine the kinds of charging infrastructure needed to support vehicle electrification,” Wei says. 

While the vast majority of people’s daily driving needs can be met by the range provided by existing lower-cost electric cars, as Trancik and her colleagues have reported, there are typically a few times when people need to drive much farther. Or, they may need to make more short trips than usual in a day, with little time to stop and recharge. These “high-energy days,” as the researchers call them, when drivers are consuming more than the usual amount of energy for their transportation needs, may only happen a handful of times per year, but they can be the deciding factor in people’s decision making about whether to go electric.

Even though battery technology is steadily improving and extending the maximum range of electric cars, that alone will not be enough to meet all drivers’ needs and achieve rapid emissions reductions. So, addressing the range issue through infrastructure is essential, Trancik says. The highest-capacity batteries tend to be the most expensive, and are not affordable to many, she points out, so getting infrastructure right is also important from an equity perspective.

Being strategic in placing infrastructure where it can be most convenient and effective — and making drivers aware of it so they can easily envision where and when they will charge — could make a huge difference, Trancik says.

“There are various ways to incentivize the expansion of such charging infrastructures,” she says. “There’s a role for policymakers at the federal level, for example, for incentives to encourage private sector competition in this space, and demonstration sites for testing out, through public-private partnerships, the rapid expansion of the charging infrastructure.” State and local governments can also play an important part in driving innovation by businesses, she says, and a number of them have already signaled their support for vehicle electrification.

Providing easy access to alternative transportation for those high-energy days could also play a role, the study found. Vehicle companies may even find it advantageous to provide or partner with convenient rental services to help drive their electric car sales.

In their analysis of driving habits in Seattle, for example, the team found that the impact of either adding highway fast-charging stations or increasing availability of supplementary long-range vehicles for up to four days a year meant that the number of homes that could meet their driving needs with a lower cost electric vehicle increased from 10 percent to 40 percent. This number rose to above 90 percent of households when fast-charging stations, workplace charging, overnight public charging, and up to 10 days of access to supplementary vehicles were all available. Importantly, charging options at residential locations (on or off-street) is key across all of these scenarios.

The study’s findings highlight the importance of making overnight charging capabilities available to more people. While those who have their own garages or off-street parking can often already easily charge their cars at home, many people do not have that option and use public parking. “It’s really important to provide access — reliable, predictable access — to charging for people, wherever they park for longer periods of time near home, often overnight,” Trancik says.

That includes locations such as hotels as well as residential neighborhoods, she says. “I think it’s so critical to emphasize these high-impact approaches, such as figuring out ways to do that on public streets, rather than haphazardly putting a charger at the grocery store or at the mall or any other public location.” Not that those aren’t also useful, she says, but public planning should be aiming to expand accessibility to a greater part of the population. Being strategic about infrastructure expansion will continue to be important even as fast chargers fall in cost and new designs begin to allow for more rapid charging, she adds.

The study should help to provide some guidance to policymakers at all levels who are looking for ways to facilitate the reduction of greenhouse gas emissions, since the transportation sector accounts for about a third of those emissions overall. “If you have limited funds, which you typically always do, then it’s just really important to prioritize,” Trancik says, noting that this study could indicate the areas that could provide the greatest return for those investments. The high-impact charging solutions they identify can be mixed and matched across different cities, towns, and regions, the reseachers note in their paper.

The researchers’ approach to analyzing high-resolution, real-world driving patterns is “valuable, enabling several opportunities for further research," says Lynette Cheah, an associate professor of engineering systems and design at Singapore University of Technology and Design, who was not associated with this work. “Real-world driving data can not only guide infrastructure and policy planning, but also optimal EV charging management and vehicle purchasing and usage decisions. … This can provide greater confidence to drivers about the feasibility and operational implications of switching to EVs.”

The study was supported by the European Regional Development Fund, the Lisbon Portugal Regional Development Program, the Portuguese Foundation for Science and Technology, and the U.S. Department of Energy.

               https://news.mit.edu/2021/electric-cars-charging-0121

Thursday, January 21, 2021

Deep Sleep Clears the Brain

Waste clearance is crucial for brain health, preventing neurodegenerative disease

By Amanda Morris, Northwestern University

January 20, 2021 -- A new Northwestern University study reaffirms the importance of getting a good night’s sleep.

By examining fruit flies’ brain activity and behavior, the researchers found that deep sleep has an ancient, restorative power to clear waste from the brain. This waste potentially includes toxic proteins that may lead to neurodegenerative disease.

“Waste clearance could be important, in general, for maintaining brain health or for preventing neurogenerative disease,” said Dr. Ravi Allada, senior author of the study. “Waste clearance may occur during wake and sleep but is substantially enhanced during deep sleep.”

The study was published today (Jan. 20) in the journal Science Advances.

Allada is the Edward C. Stuntz Distinguished Professor in Neuroscience and chair of the Department of Neurobiology in the Northwestern’s Weinberg College of Arts and Sciences. He also is associate director of Northwestern’s Center for Sleep and Circadian Biology and a member of the Chemistry of Life Processes Institute.  Bart van Alphen, a postdoctoral fellow in Allada’s laboratory, was the paper’s first author. 

Although fruit flies seem very different from humans, the neurons that govern flies’ sleep-wake cycles are strikingly similar to our own. For this reason, fruit flies have become a well-studied model organism for sleep, circadian rhythms and neurodegenerative diseases.

In the current study, Allada and his team examined proboscis extension sleep, a deep-sleep stage in fruit flies, which is similar to deep, slow-wave sleep in humans. The researchers discovered that, during this stage, fruit flies repeatedly extend and retract their proboscis (or snout).

“This pumping motion moves fluids possibly to the fly version of the kidneys,” Allada said. “Our study shows that this facilitates waste clearance and aids in injury recovery.”

When Allada’s team impaired flies’ deep sleep, the flies were less able to clear an injected non-metabolizable dye from their systems and were more susceptible to traumatic injuries. 

Allada said this study brings us closer to understanding the mystery of why all organisms need sleep. All animals — especially those in the wild — are incredibly vulnerable when they sleep. But research increasingly shows that the benefits of sleep — including crucial waste removal — outweigh this increased vulnerability.

“Our finding that deep sleep serves a role in waste clearance in the fruit fly indicates that waste clearance is an evolutionary conserved core function of sleep,” the paper’s coauthors write. “This suggests that waste clearance may have been a function of sleep in the common ancestor of flies and humans.” 

https://news.northwestern.edu/stories/2021/01/deep-sleep-takes-out-the-trash/

Wednesday, January 20, 2021

The Ongoing Collapse of the World's Aquifers

When humans over-exploit underground water supplies, the ground collapses like a huge empty water bottle. It's called subsidence, and it could affect 1.6 billion people by 2040.

Matt Simon from Wired reported on January 19, 2021 that the world’s underground fresh water  supplies are being deleted, resulting in collapsed ground and too little well water being available.  See https://www.wired.com/story/the-ongoing-collapse-of-the-worlds-aquifers

Tuesday, January 19, 2021

The “Deep State” Speaks Aloud

 By the Blog Author

I have news for you.  The “Deep State” consists of heroes who are modest about their accomplishments.  These are the names left anonymous in the lobby of the Central Intelligence Agency because to know them and their accomplishments would endanger other agents and decrease the input of accurate information to the agency.  The deep state includes FBI agents who investigate foreign citizens here in the United States who are spying on us for another nation. 

They are modest to a fault.  They are patriotic.  They are furiously competent.  We owe them a lot, especially since they were smeared incessantly by Donald Trump, beginning in August of 2016.

 I have found a lot of news articles – more than 3,000! -- for my daily blog and many for my mentoring course.  I’ll bet you didn’t know there is a video-free, audio only regular program on the internet called “Deep State Radio” but I found it easily.  This remarkable show features the voices of prosecuting attorneys, specialists and experts who don’t need fame but thoroughly know what they are talking about.

“Deep State Radio” even talks calmly for 47 minutes about the assault on the Capitol on January 6:

https://shows.acast.com/deepstateradio/episodes/ask-the-experts-how-do-we-make-january-6-a-positive-turning

Twice a week, this podcast will take you on a smart, direct, sometimes scary, sometimes profane, sometimes hilarious tour of the inner workings of American power and of the impact of our leaders and their policies on our standing in the world. Hosted by noted author and commentator David Rothkopf and featuring regulars Rosa Brooks of Georgetown Law School, Kori Schake of Stanford University and David Sanger of the New York Times, the program will be the lively, smart dinner table conversation on the big issues of the day that you wish you were having...without the calories. Sometimes special guests will join the conversation and always the emphasis will be on providing the unvarnished perspectives others shy away from. Deep State Radio is the insider perspective on American national security and foreign policy that you can't find anywhere else.If you are enjoying this podcast, please consider becoming a member by visiting thedsrnetwork.com or supporting our show by making a donation by visiting https://supporter.acast.com/deepstateradio.Support this show http://supporter.acast.com/deepstateradio. See acast.com/privacy for privacy and opt-out information.


rmation.

Monday, January 18, 2021

Rock and Roll's Phil Spector Dies

 Harvey Phillip Spector (December 26, 1939 – January 16, 2021) was an American record producer, musician, and songwriter known for his innovative recording practices and entrepreneurship in the 1960s, followed decades later by his trial and conviction for murder in the 2000s. Spector developed the Wall of Sound, a music production formula he described as a Wagnerian approach to rock and roll.  He is regarded as one of the most influential figures in pop music history and as the first auteur of the music industry for the unprecedented control he had over every phase of the recording process.  After spending three decades in semi-retirement, in 2009 he was convicted for the 2003 murder of the actress Lana Clarkson and sentenced to 19 years to life in prison.

Born in The Bronx, Spector began his career in 1958 as co-founder, guitarist, and vocalist of the Teddy Bears, penning their U.S. number-one single "To Know Him Is to Love Him". In 1960, he co-founded Philles Records, and at the age of 21 became the youngest ever U.S. label owner to that point.  Throughout the 1960s, he wrote, co-wrote, or produced records for acts such as the Ronettes, the Crystals, and Ike & Tina Turner. He typically collaborated with arranger Jack Nitzsche, engineer Larry Levine, and a de facto house band that later became known as "the Wrecking Crew". Spector initially retired from the music industry in 1966.

In 1969, Spector returned to his career and subsequently produced the Beatles'[last] album [together] Let It Be (1970), as well as several solo records by the band's John Lennon and George Harrison.  By the mid-1970s, Spector had produced eighteen U.S. Top 10 singles for various artists, but following work with Leonard Cohen, Dion DiMucci, and the Ramones, he remained largely inactive and affected by personal struggles.  His chart-toppers inclued "You've Lost That Lovin' Feelin’" (co-written and produced for the Righteous Brothers, 1964), "The Long and Winding Road" (produced for the Beatles, 1970), and "My Sweet Lord" (produced for Harrison, 1970). According to BMI, "You've Lost That Lovin' Feelin'" is the song that received the most US airplay in the 20th century.

Dubbed the "First Tycoon of Teen", Spector helped engender the role of the studio as an instrument, the integration of pop art aesthetics into music (art pop), and the genres of art rock and dream pop.  His multi-artist compilation album A Christmas Gift for You from Philles Records (1963) is widely considered to be the finest Christmas record of all time.  Spector's honors include the 1973 Grammy Award for Album of the Year for co-producing Harrison's Concert for Bangladesh (1971), a 1989 induction into the Rock and Roll Hall of Fame, and a 1997 induction into the Songwriters Hall of Fame.  In 2004, Rolling Stone magazine ranked Spector number 63 on their list of the greatest artists in history.  In 2021, he died of COVID-19 in prison at the age of 81.

Musicianship

Spector's trademark during his recording career was the so-called Wall of Sound, a production technique yielding a dense, layered effect that reproduced well on AM radio and jukeboxes.  To attain this signature sound, Spector gathered large groups of musicians (playing some instruments not generally used for ensemble playing, such as electric and acoustic guitars) playing orchestrated parts—often doubling and tripling many instruments playing in unison—for a fuller sound. Spector himself called his technique "a Wagnerian approach to rock & roll: little symphonies for the kids".

While Spector directed the overall sound of his recordings, he took a relatively hands-off approach to working with the musicians themselves (usually a core group that became known as the Wrecking Crew, including session players such as Hal Blaine, Larry Knechtel, Steve Douglas, Carol Kaye, Roy Caton, Glen Campbell, and Leon Russell), delegating arrangement duties to Jack Nitzsche and having Sonny Bono oversee the performances, viewing these two as his "lieutenants".  Spector frequently used songs from songwriters employed at the Brill Building (Trio Music) and at 1650 Broadway (Aldon Music), such as the teams of Ellie Greenwich and Jeff Barry, Barry Mann and Cynthia Weil, and Gerry Goffin and Carole King. He often worked with the songwriters, receiving co-credit and publishing royalties for compositions.

Despite the trend towards multichannel recording, Spector was vehemently opposed to stereo releases, saying that it took control of the record's sound away from the producer in favor of the listener.  Spector was more concerned with the overall collage of sound than with the recording fidelity or timbral quality.  Sometimes a pair of strings or horns would be double-tracked multiple times to sound like an entire string or horn section. But in the final product the background sometimes could not be distinguished as either horns or strings. Spector also greatly preferred singles to albums, describing LPs as "two hits and ten pieces of junk", reflecting both his commercial methods and those of many other producers at the time.

Murder Conviction

On February 3, 2003, Spector shot actress Lana Clarkson in the mouth while in his mansion (the Pyrenees Castle) in Alhambra, California. Her body was found slumped in a chair with a single gunshot wound to her mouth. Spector told Esquire in July 2003 that Clarkson's death was an "accidental suicide" and that she "kissed the gun".  The emergency call from Spector's home, made by Spector's driver, Adriano de Souza, quotes Spector as saying, "I think I've killed somebody". De Souza added that he saw Spector come out of the back door of the house with a gun in his hand.

The retrial of Spector for murder in the second degree began on October 20, 2008, with Judge Fidler again presiding; the retrial was not televised. Spector was once again represented by attorney Jennifer Lee Barringer.  The case went to the jury on March 26, 2009, and 18 days later, on April 13, the jury returned a guilty verdict.  Additionally, Spector was found guilty of using a firearm in the commission of a crime, which added four years to the sentence.  He was immediately taken into custody and, on May 29, 2009, was sentenced to 19 years to life in the California state prison system.  At the time of his death, he was an inmate at the California Health Care Facility in Stockton, California.  He would have been eligible for parole in 2024.

Death in 2021

 In 2021 [January 16th], he died of COVID-19 in prison at the age of 81.

His legacy is mixed. Spector was a “genius irredeemably conflicted” according to Stevie Van Zandt, a member of Bruce Springsteen’s E Street Band and host of Little Steven’s Underground Garage on Sirius Radio. He tweeted: "He was the ultimate example of the art always being better than the artist" ... and "made some of the greatest records in history based on the salvation of love while remaining incapable of giving or receiving love his whole life."

               https://en.wikipedia.org/wiki/Phil_Spector